NLRP12 Antibodies

AND NLRP12 ELISA kits, NLRP12 Proteins

Many biological assays use antibodies to detect NLRP12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NLRP12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NLRP12 antibodies...

We validate the specificity of these antibodies to NLRP12 by testing them on tissues known to express NLRP12 positively and negatively. Browse below to find the NLRP12 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NLRP12 Infographic by Boster Bio

All NLRP12 Products

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Specificity

Applications

Price

Anti-NALP12 NLRP12 Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A02124
0.1 mg

NALP12 (NLRP12) (NM_033297) Human Over-expression Lysate

Human

$628
Cat # LS091662
100 µg

NLRP12 Overview

Facts about NACHT, LRR and PYD domains-containing protein 12.

NLRP12 3D structure. Source: alphafold

NACHT, LRR and PYD domains-containing protein 12 (NLRP12)

May mediate activation of CASP1 Through ASC and promote activation of NF-kappa-B Through IKK.
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Gene Information

Human
Gene Name:	NLRP12
Uniprot:	P59046
Entrez:	91662

Family

Belongs to:

NLRP family

Alternative Names

FCAS2; Monarch-1; NACHT, leucine rich repeat and PYD containing 12; NACHT, LRR and PYD domains-containing protein 12; NALP12LRR and PYD containing protein 12; NLR family, pyrin domain containing 12; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 12; PYPAF7Monarch1; PYRIN-containing APAF1-like protein 7; Regulated by nitric oxide; RNO2

Molecular Weight

Mass (kDA):
120.173 kDA

Genomic Context


Human

Location:	19q13.42
Sequence:	19; NC_000019.10 (53793584..53824403, complement)

Tissue Specificity

Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.

Subcellular Localizations

Cytoplasm.

Diseases

Inflammation
Hereditary Autoinflammatory Diseases
Familial Mediterranean Fever
Neoplasms
Autoimmune Diseases
Inflammatory Response
Cell Transformation, Neoplastic
Malignant Neoplasms
Hereditary Diseases
Dermatitis, Atopic
Contact Hypersensitivity
Colitis

Dermatitis
Autoimmune Reaction
Autoimmunity
Coronary Heart Disease
Embryonal Carcinoma
Melanoma

Pathways

Pathogenesis
Secretion
Inflammatory Response
Immune Response
Hypersensitivity
Hyperphosphorylation
Cell Activation
Cell Proliferation
Cell Migration
Proteolysis

Virulence
Cell Maturation
Innate Immune Response
Cell Differentiation
Rna Interference

PTMs

Phosphorylation

Acetylation

Research Areas

Apoptosis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NLRP12

References

PMID: 12019269 by Wang L., et al. PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing.

PMID: 12563287 by Tschopp J., et al. NALPs: a novel protein family involved in inflammation.