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Homeobox protein Nkx-6.2 Antibodies
AND NKX6-2 ELISA kits, Homeobox protein Nkx-6.2 Proteins
Many biological assays use antibodies to detect Homeobox protein Nkx-6.2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Homeobox protein Nkx-6.2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Homeobox protein Nkx-6.2 antibodies...
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NKX6-2 Overview
Facts about Homeobox protein Nkx-6.2.
Homeobox protein Nkx-6.2 (NKX6-2)
Transcription factor with repressor activity involved in the regulation of axon-glial interactions in myelin paranodes in oligodendrocytes. Binds to the consensus DNA sequence 5'- (A/T)TTAATGA-3'.
In oligodendrocytes, binds to MBP and PLP1 promoter regions. .
Gene Information
| Human | |
|---|---|
| Gene Name: | NKX6-2 |
| Uniprot: | Q9C056 |
| Entrez: | 84504 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Homeobox protein Nkx-6.2
Molecular Weight
Mass (kDA):
29.263 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q26.3 |
| Sequence: | 10; NC_000010.11 (132782229..132786147, complement) |
Tissue Specificity
Highest expression in brain.
Subcellular Localizations
Nucleus.
Diseases
- Spastic ataxia 8, autosomal recessive, with hypomyelinating leukodystrophy (SPAX8)
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NKX6-2
bosterbio.com/bosterbio-gene-info-cards/NKX6-2
References
PMID: 11210186 by Lee S.-H., et al. Cloning, expression and chromosomal location of NKX6B to 10q26, a region frequently deleted in brain tumors.
PMID: 28575651 by Chelban V., et al. Mutations in NKX6-2 Cause Progressive Spastic Ataxia and Hypomyelination.