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- Table of Contents
Facts about NF-kappa-B inhibitor zeta.
Inhibits DNA-binding of both RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF- kappa-B-mediated transcription.
Human | |
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Gene Name: | NFKBIZ |
Uniprot: | Q9BYH8 |
Entrez: | 64332 |
Belongs to: |
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No superfamily |
FLJ30225; FLJ34463; ikappaBzeta; I-kappa-B-zeta; IkappaB-zeta; ikbzeta; IkB-zeta; IL-1 inducible nuclear ankyrin-repeat protein; INAPIkappa B-zeta variant 3; MAILIKBZikB-zeta; Molecule possessing ankyrin repeats induced by lipopolysaccharide; NF-kappa-B inhibitor zeta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor
Mass (kDA):
78.061 kDA
Human | |
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Location: | 3q12.3 |
Sequence: | 3; NC_000003.12 (101827990..101861022) |
Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart.
Nucleus. Aggregated in dot-like structures. Colocalizes with NCOR2.
PMID: 16513645 by Totzke G., et al. A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding.
PMID: 16622025 by Cowland J.B., et al. IL-1beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IkappaB-zeta.