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- Table of Contents
Facts about Neuralized-like protein 2.
Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity).
Human | |
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Gene Name: | NEURL2 |
Uniprot: | Q9BR09 |
Entrez: | 140825 |
Belongs to: |
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No superfamily |
C20orf163; chromosome 20 open reading frame 163; dJ337O18.6; FLJ30259; MGC125934; MGC125935; neuralized homolog 2 (Drosophila); neuralized-like 2 (Drosophila); neuralized-like 2; neuralized-like protein 2; OZZ; Ozz-E3
Mass (kDA):
31.69 kDA
Human | |
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Location: | 20q13.12 |
Sequence: | 20; NC_000020.11 (45888472..45891287, complement) |
Expressed specifically in skeletal and cardiac muscles.
Cytoplasm.
PMID: 14960280 by Nastasi T., et al. Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis.