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- Table of Contents
Facts about Neudesin.
Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme.
Human | |
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Gene Name: | NENF |
Uniprot: | Q9UMX5 |
Entrez: | 29937 |
Belongs to: |
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cytochrome b5 family |
Cell immortalization-related protein 2; CIR2; CIR2cell growth-inhibiting protein 47; NENF; Neudesin; neuron derived neurotrophic factor; Neuron-derived neurotrophic factor; SCIRP10; SCIRP10-related protein; Secreted protein of unknown function; Spinal cord injury related protein 10; SPUF protein; SPUF; SPUFneudesin
Mass (kDA):
18.856 kDA
Human | |
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Location: | 1q32.3 |
Sequence: | 1; NC_000001.11 (212432920..212446379) |
Ubiquitously expressed with high expression in heart. Over-expressed in various tumors including carcinomas of the uterine cervix, lymphoma, colon, lung, skin and leukemia, as well as carcinoma of the breast.
Secreted, extracellular space. Mitochondrion. Endoplasmic reticulum. Localized to mitochondria and endoplasmic reticulum by PINK1 and PARK7.
PMID: 15605373 by Kimura I., et al. Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity.
PMID: 9771976 by Ma L., et al. Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines.