NEK3 Antibodies

AND NEK3 ELISA kits, NEK3 Proteins

Many biological assays use antibodies to detect NEK3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NEK3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NEK3 antibodies...

We validate the specificity of these antibodies to NEK3 by testing them on tissues known to express NEK3 positively and negatively. Browse below to find the NEK3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NEK3 Infographic by Boster Bio

All NEK3 Products

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Product

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Specificity

Applications

Price

Anti-NEK3 Antibody

Human, Mouse, Rat

$405
Cat # A09729
100ul

NEK3 (NM_002498) Human Over-expression Lysate

Human

$628
Cat # LS004752
100 µg

NEK3 Overview

Facts about Serine/threonine-protein kinase Nek3.

NEK3 3D structure. Source: alphafold

Serine/threonine-protein kinase Nek3 (NEK3)

Protein kinase which affects neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons.

Contributes to prolactin- mediated phosphorylation of PXN and VAV2. Implicated in prolactin- mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.

Gene Information

Human
Gene Name:	NEK3
Uniprot:	P51956
Entrez:	4752

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11; EC 2.7.11.1; glycogen synthase A kinase; HSPK 36; HSPK36; hydroxyalkyl-protein kinase; MGC29949; Never in mitosis A-related kinase 3; NIMA (never in mitosis gene a)-related kinase 3; NimA-related protein kinase 3; phosphorylase B kinase kinase; serine/threonine-protein kinase Nek3

Molecular Weight

Mass (kDA):
57.705 kDA

Genomic Context


Human

Location:	13q14.3
Sequence:	13; NC_000013.11 (52132643..52159597, complement)

Tissue Specificity

Up-regulated in malignant versus normal breast tissue. Isoform 2 shows a high level of expression in testis, ovary and brain.

Subcellular Localizations

Cytoplasm. Cell projection, axon.

Diseases

Malignant Neoplasms
Mammary Neoplasms
Malignant Neoplasm Of Breast
Malignant Paraganglionic Neoplasm
Neoplasms
Cell Invasion
Stomach Neoplasms
Malignant Neoplasm Of Prostate
Lung Neoplasms
Liver Carcinoma
Malignant Neoplasm Of Liver
Cholera
Atherosclerosis

Neoplasm Invasiveness
Carcinoma
Tumor Angiogenesis
Prostatic Neoplasms
Leukemia
Inflammation
Liver Neoplasms

Interacting Proteins

VAV2

Pathways

Mitosis
Localization
Cell Cycle
Endocytosis
Transport
Dna Replication
Intracellular Transport
Cell Migration

Angiogenesis
Interphase
Secretion

PTMs

Phosphorylation

Deacetylation

Acetylation

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NEK3

References

PMID: 12063396 by Kimura M., et al. Molecular cloning and characterization of the human NIMA-related protein kinase 3 gene (NEK3).

PMID: 7522034 by Schultz S.J., et al. Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans.