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- Table of Contents
Facts about Endonuclease 8-like 2.
Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.
Human | |
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Gene Name: | NEIL2 |
Uniprot: | Q969S2 |
Entrez: | 252969 |
Belongs to: |
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FPG family |
DNA glycosylase/AP lyase Neil2; EC 3.2.2.-; EC 4.2.99.18; endonuclease 8-like 2; Endonuclease VIII-like 2; FLJ31644; MGC2832; MGC4505; NEH2DNA-(apurinic or apyrimidinic site) lyase Neil2; nei endonuclease VIII-like 2 (E. coli); Nei homolog 2; nei like 2 (E. coli); nei like 2; NEI2; Nei-like protein 2
Mass (kDA):
36.826 kDA
Human | |
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Location: | 8p23.1 |
Sequence: | 8; NC_000008.11 (11769710..11787345) |
Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver.
Nucleus.
PMID: 12200441 by Takao M., et al. A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue.
PMID: 12097317 by Hazra T.K., et al. Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions.