Nectin-4 Antibodies

Nectin-4 (Nectin4)

Appears to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. .

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Gene Information

Mouse
Gene Name:	Nectin4
Uniprot:	Q8R007
Entrez:	71740

Family

Belongs to:
nectin family

Alternative Names

EDSS1; Ig superfamily receptor LNIR; LNIR; LNIRnectin 4; Nectin4; Nectin-4; poliovirus receptor-related 4; poliovirus receptor-related protein 4; PRR4; PRR4DKFZp686K05193; PVRL4

Molecular Weight

Mass (kDA):
55.657 kDA

Genomic Context

Mouse
Location:	1|1 H3
Sequence:	1;

Tissue Specificity

Expressed in brain, lung, testis and embryo.

Diseases

• Tissue Adhesions
• Measles
• Malignant Neoplasms
• Neoplasms
• Ectodermal Dysplasia
• Dysplasia
• Syndactyly
• Infective Disorder
• Adenocarcinoma
• Neoplasm Metastasis
• Malignant Neoplasm Of Breast
• Respiration Disorders

• Malignant Neoplasm Of Lung
• Carcinoma
• Tooth Abnormalities
• Nervousness
• Mammary Neoplasms
• Cleft Lip
• Neuroblastoma

Pathways

• Cell Adhesion
• Localization
• Virion Assembly
• Transport
• Pathogenesis
• Lymphocyte Activation

PTMs

• Biotinylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Nectin4

The Boster Bio: Best Uses Of The NECTIN4 Marker

The Boster Bio: Best Uses of the Nectin4 Marker provides information about the biological functions of this marker. The guide offers numerous tips to optimize your research and improving results. During the course of an experiment, every researcher will experience some kind of difficulty. The majority times problems can be eliminated by implementing proper procedures. Troubleshooting guides are also helpful in identifying root cause of the error.

Serum Nectin-4 can be used to assess the effectiveness of therapeutics

In clinical studies the tests of serum Nectin-4 levels correlate with clinical progress and response. In 95% of cases the levels of serum Nectin-4 are correlated with the clinical outcome. The clinical response was strongly associated with the serum Nectin-4 levels in this study. Additionally the serum Nectin-4 levels were found to be an excellent indicator of the effectiveness of treatment.

Boster Bio serum Nectin-4 levels help measure the effectiveness of cancer treatment. They are measured by patients before and after treatment. Arrows indicate changes, decreases, extinction and unchanged levels. The corresponding patient outcomes were evaluated based on clinical and histoclinical criteria.

Clinical studies indicate that the levels of Nectin-4 correlate with basal-like breast markers such as CD45 however they are not correlated with luminal-like markers. Nectin-4 expression could not be used to identify tumors that express active TACE in combination with Nectin-4. This finding isn't relevant in the context clinical trials of treatments for cancer.

Normal breast tissue does not contain Nectin-4. Its expression was not found in luminal cells, myoepithelial cells, or stromal cells. Nectin-4 expression was highest in ductal cancer cells. In tumors, Nectin-4 expression correlates with subtype markers of the basal subtype. Breast cancer metastatic is diagnosed using reliable serum markers such as Nectin-4.

There are many biochemical methods that can be employed to determine the concentration of Nectin-4. For example the use of immunohistochemistry to assess the level of this soluble protein within tumor cells. In patients with cancer there is a decrease in Nectin-4 in their serum can indicate a positive response to therapy. This is a useful marker in the prognosis for patients who are receiving chemotherapy.

In addition, patients suffering from advanced breast cancer might be eligible to receive this treatment. The blood test Nectin-4 test is also helpful to determine whether a tumor has responded to a specific chemotherapy drug. The study showed that it was linked to basal-like cells and non-ER/PR-positive tumors. However, the results aren't conclusive evidence of a connection between Nectin-4 and breast cancer.

It is an anti-tumor antibody

Tumor-associated antibody (TAA), is a virus-related product that can be found within the cell's nucleus , or cytoplasm. The protein is made by cancer cells and relies on the virus that caused transformation. In cancer, tumour-associated antigen (TAA) is produced by cells containing certain DNA viruses. This antigen is often expressed in aggressive tumours and can spread quickly.

It is a determinant of histological and serological tumor associations

Scientists have recently published that NECTIN4 levels in serum are a useful marker for the histological, and serological relationship of breast carcinoma. More than 90 percent of cases revealed an association between the levels of NECTIN4 and the progression of the disease. However, these associations did not depend on the presence of other tumor-related proteins, or clinical variables. This article will review the clinical relevance of serum NECTIN4 levels the diagnosis of breast cancer as well as lung cancer.

NECTIN-4, an overexpressed part of the Nectin family of Ca2+ dependent immunoglobulin like cell adhesion molecules is a Ca2+-independent molecule. This gene is located in the placenta and embryo. It is associated with poor prognosis. Nectin-4 expression is associated with poor prognosis for various tumors, including HCC (hepatocellular carcinoma).

In a study of twenty patients suffering from HCC, the mRNA levels of Nectin-4 was assessed using a quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) assay. NECTIN-4 expression was significantly more prominent in tumors than non-tumor tissue. The levels of positive expression in tumors were significantly higher than the levels observed in non-tumor tissues.

Takano and colleagues used NECTIN4 serum to detect tumors. The presence of Nectin-4 was a significant predictor of poor prognosis among NSCLC patients. Using an in vitro model they discovered that tumor cells that express nectin 4 exhibited an increase in lamellipodia development and invaded via activation of the small GTPase Rac1. Short interferingRNA directed against Nectin-4 also inhibited cell proliferation in the lungs.

It is a symptom of canine distemper virus infection

Researchers have discovered that nectin-4 is a receptor for the canine distemper virus, which is present in cerebrospinal fluid, which circulates in. This receptor is crucial in helping to facilitate the spread of the virus to the central nervous system. A previous study by Martella V. and colleagues demonstrated that nectin-4 can be a marker for canine distemper infection. This marker could aid veterinarians to diagnose canine distemper viral infection.

How the disease progresses depends on how severe the infection is and how much immunosuppression there is. The virus is killed by the immune system in mild instances. In more serious cases, the virus could take over the animal's weak immune system and move into the second stage of viraemic disease. This is when dogs begin to exhibit symptoms of canine distemper virus infection. This indicator can be used to confirm cerebral distemper.

Canine distemper virus is a highly transmissible viral disease of domestic dogs and a few wild species. Despite the fact that the domestic dog populations have been vaccinated the disease is still widespread and can trigger occasional outbreaks. The disease typically affects puppies between three and six months old. Because of this vulnerability, puppies of young age suffer more severe illness. Older dogs that have not been vaccinated are vulnerable to infection.

Genotypes are the antigenic distinctions among the various strains of canine viruses. German research has identified five genotypes of canine distemper virus: Anis E. Mamaev L. Maack D. and Barrett T. A genetic analysis by Blixenkrone Müller M has revealed that the antigenic differences among canine distemper strains are mostly due to antigenic differences in the hemagglutinin genes.