NECAB2 Antibodies

AND NECAB2 ELISA kits, NECAB2 Proteins

Many biological assays use antibodies to detect NECAB2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NECAB2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NECAB2 antibodies...

We validate the specificity of these antibodies to NECAB2 by testing them on tissues known to express NECAB2 positively and negatively. Browse below to find the NECAB2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NECAB2 Infographic by Boster Bio

All NECAB2 Products

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Product

Figures

Specificity

Applications

Price

EFCBP2 (NECAB2) (NM_019065) Human Recombinant Protein

$1249
Cat # PROTQ7Z6G3
20 µg

EFCBP2 (NECAB2) (NM_019065) Human Over-expression Lysate

Human

$628
Cat # LS054550
100 µg

Anti-NECAB2 Antibody Picoband®

Human

ELISA, Flow Cytometry, WB

$370
Cat # A13886-2
100 µg/vial

NECAB2 Overview

Facts about N-terminal EF-hand calcium-binding protein 2.

NECAB2 3D structure. Source: alphafold

N-terminal EF-hand calcium-binding protein 2 (NECAB2)

May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation.

Gene Information

Human
Gene Name:	NECAB2
Uniprot:	Q7Z6G3
Entrez:	54550

Family

Belongs to:

No superfamily

Alternative Names

EF-hand calcium binding protein 2; N-terminal EF-hand calcium binding protein 2

Molecular Weight

Mass (kDA):
43.194 kDA

Genomic Context


Human

Location:	16q23.3
Sequence:	16; NC_000016.10 (83968632..84002776)

Tissue Specificity

Expressed in brain. Expressed in the spinal dorsal horn with especially strong expression in lamina IIi; found in excitory synaptic boutons and in ependymal cells (at protein level).

Subcellular Localizations

Cytoplasm. Cell projection, dendrite. Cell projection, axon. Cell membrane. Colocalizes with ADORA2A and/or mGluR5/GRM5 at the plasma membrane (PubMed:17689978, PubMed:19694902). Found in neuronal somata (PubMed:26843217). Detected in the cytoplasm of striatal neurons, at postsynaptic sites, filling dendritic shafts and spines, and at presynaptic sites, filling axon terminals (By similarity).

Diseases

Child Development Disorders, Pervasive
Autistic Disorder
Autism Spectrum Disorders

Interacting Proteins

ADORA2A
AIMP2
BEX2
BEX3
BYSL

C1orf109
CARD9
CCDC151
CCDC153
CENPO

DAXX
EHHADH
EIF4E2
FAM161A
GCC1

HAUS1
ISCU
KANSL1
KIFC3
KLC3

KLC4
KPNA2
LENG1
LNX1
NECAB1

NEK6
NIP7
OIP5
PRKAA2
RCOR3

SDCBP
SH2D4A
SSC5D
TTC25
TTR

WDYHV1

Pathways

Eye Morphogenesis

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NECAB2

References

PMID: 12044471 by Sugita S., et al. NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern.

PMID: 17689978 by Canela L., et al. The neuronal Ca(2+) -binding protein 2 (NECAB2) interacts with the adenosine A(2A) receptor and modulates the cell surface expression and function of the receptor.