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- Table of Contents
Facts about Nuclear distribution protein nudE-like 1.
Also positively regulates the activity of this minus-end directed microtubule motor protein dynein. May improve dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends.
Human | |
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Gene Name: | NDEL1 |
Uniprot: | Q9GZM8 |
Entrez: | 81565 |
Belongs to: |
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nudE family |
DKFZp451M0318; EOPA; MITAP1mitosin-associated protein MITAP1; Mitosin-associated protein 1; nuclear distribution protein nudE-like 1; nudE nuclear distribution gene E homolog (A. nidulans)-like 1; nudE nuclear distribution gene E homolog like 1 (A. nidulans); nudE nuclear distribution gene E homolog like 1; NUDELendooligopeptidase A; NUDE-like protein; Protein Nudel
Mass (kDA):
38.375 kDA
Human | |
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Location: | 17p13.1 |
Sequence: | 17; NC_000017.11 (8435884..8472744) |
Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the kinetochore in a CENPF-dependent manner.
PMID: 11163260 by Niethammer M., et al. NUDEL is a novel cdk5 substrate that associates with LIS1 and cytoplasmic dynein.
PMID: 12556484 by Yan X., et al. Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle.