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NDE1 Antibodies
AND NDE1 ELISA kits, NDE1 Proteins
Many biological assays use antibodies to detect NDE1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NDE1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NDE1 antibodies...
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NDE1 Overview
Facts about Nuclear distribution protein nudE homolog 1.
Nuclear distribution protein nudE homolog 1 (NDE1)
Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the growth of the cerebral cortex.
May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the mind. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post- mitotic neuron.
Gene Information
| Human | |
|---|---|
| Gene Name: | NDE1 |
| Uniprot: | Q9NXR1 |
| Entrez: | 54820 |
Family
| Belongs to: |
|---|
| nudE family |
Alternative Names
FLJ20101; HOM-TES-87; nuclear distribution protein nudE homolog 1; nudE nuclear distribution gene E homolog 1 (A. nidulans); NudE; NUDE1; rat homolog
Molecular Weight
Mass (kDA):
37.721 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p13.11 |
| Sequence: | 16; NC_000016.10 (15643267..15726353) |
Tissue Specificity
Expressed in the neuroepithelium throughout the developing brain, including the cerebral cortex and cerebellum.
Subcellular Localizations
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Localizes to the interphase and S phase centrosome. During mitosis, partially associated with the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF-dependent manner. Also localizes to the cleavage furrow during cytokinesis. manner. Also localizes to the cleavage furrow during cytokinesis.
Diseases
- Schizophrenia
- Lissencephaly
- Mental Disorders
- Microcephaly
- Autistic Disorder
- Leukemia
- Malignant Neoplasms
- Neoplasms
- Malignant Paraganglionic Neoplasm
- Depressive Disorder
- Bipolar Disorder
- Microlissencephaly
Interacting Proteins
- NDEL1
- ZNF365
Pathways
- Mitosis
- Cell Division
- Transport
- Neurogenesis
- Localization
- Electron Transport
- Electron Transport Chain
- Cell Death
- Pathogenesis
- Chromosome Segregation
- Cell Cycle
- Metaphase
- Rna Interference
PTMs
- Phosphorylation
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NDE1
bosterbio.com/bosterbio-gene-info-cards/NDE1
References
PMID: 12556484 by Yan X., et al. Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle.
PMID: 16291865 by Guo J., et al. Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly.