NCOR2 Antibodies

AND NCOR2 ELISA kits, NCOR2 Proteins

Many biological assays use antibodies to detect NCOR2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NCOR2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NCOR2 antibodies...

We validate the specificity of these antibodies to NCOR2 by testing them on tissues known to express NCOR2 positively and negatively. Browse below to find the NCOR2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NCOR2 Infographic by Boster Bio

All NCOR2 Products

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Product

Figures

Specificity

Applications

Price

Anti-SMRTe (K535) NCOR2 Antibody

Human, Mouse, Rat

$405
Cat # A01412
100ul

Anti-SMRTe NCOR2 Antibody

Human

ELISA, IF, IHC

$380
Cat # A01412-1
100ul

Anti-NCOR2 Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A01412-2
100 µg/vial

NCOR2 Overview

Facts about Nuclear receptor corepressor 2.

NCOR2 3D structure. Source: alphafold

Nuclear receptor corepressor 2 (NCOR2)

Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.

Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal centre (GC) reactions, mainly through the control of the GC B-cells proliferation and survival.

Gene Information

Human
Gene Name:	NCOR2
Uniprot:	Q9Y618
Entrez:	9612

Family

Belongs to:

N-CoR nuclear receptor corepressors family

Alternative Names

CTG repeat protein 26; CTG26; CTG26nuclear receptor co-repressor 2; FLJ25011; NCOR2; N-CoR2; nuclear receptor corepressor 2; retinoic-acid-receptor-associated corepressor; silencing mediator for retinoid and thyroid hormone receptors; SMAP270; SMRT; SMRTE; SMRTE-tau; SMRTT3 receptor-associating factor; TNRC14; TRAC; TRAC1; TRAC-1

Molecular Weight

Mass (kDA):
273.657 kDA

Genomic Context


Human

Location:	12q24.31
Sequence:	12; NC_000012.12 (124324415..124567612, complement)

Tissue Specificity

Ubiquitous. High levels of expression are detected in lung, spleen and brain.

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Breast
Leukemia
Mammary Neoplasms
Acute Promyelocytic Leukemia
Malignant Neoplasm Of Prostate
Lymphoma
Malignant Paraganglionic Neoplasm
Prostatic Neoplasms
Carcinoma
Refractory Anemia With Ringed Sideroblasts
Chromosomal Translocation

Myeloid Leukemia
Cell Transformation, Neoplastic
B-cell Lymphomas
Leukemia, Myelocytic, Acute
Leukemogenesis
Traditional Serrated Adenoma
Thyroid Hormone Resistance Syndrome

Interacting Proteins

AHR
ARNT
E2F1
Gmnn
HDAC1

HDAC3
RARA
RBPJ
SNW1
SPEN

TP53

Pathways

Cell Cycle
Localization
Cell Proliferation
Pathogenesis
Cell Growth
Histone Deacetylation
Cell Differentiation
Chromatin Remodeling
Histone Acetylation
Oncogenesis
Gene Silencing
Chromatin Modification
Cholesterol Homeostasis

Regulation Of Gene Expression
Cell Cycle Arrest
Inflammatory Response
Rna Interference
Cell Activation
T Cell Activation
Nuclear Export

PTMs

Phosphorylation
Acetylation
Deacetylation

Methylation
Sumoylation
Nitration

Biotinylation

Research Areas

Cancer
Chromatin Research
Transcription Factors and Regulators

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NCOR2

References

PMID: 8813722 by Sande S., et al. Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors.

PMID: 10077563 by Ordentlich P., et al. Unique forms of human and mouse nuclear receptor corepressor SMRT.