RING-box protein 2 (RNF7)

Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:10851089). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating inclusion of the first ubiquitin on CRLs targets (By similarity).

Through the RING-type zinc finger, seems to permeate the E2 ubiquitination receptor into the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 through its interaction with UBE2F.