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- Table of Contents
Facts about RING-box protein 2.
Through the RING-type zinc finger, seems to permeate the E2 ubiquitination receptor into the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 through its interaction with UBE2F.
Human | |
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Gene Name: | RNF7 |
Uniprot: | Q9UBF6 |
Entrez: | 9616 |
Belongs to: |
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RING-box family |
CKBBP1zinc RING finger protein SAG; CKII beta-binding protein 1; RBX2; Regulator of cullins 2; ring finger protein 7rbx2; ROC2RING-box protein 2; SAGsensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2; Sensitive to apoptosis gene protein
Mass (kDA):
12.683 kDA
Human | |
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Location: | 3q23 |
Sequence: | 3; NC_000003.12 (141738209..141747560) |
Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in brain, placenta and lung.
Cytoplasm. Nucleus.
PMID: 10512750 by Son M.-Y., et al. Protein kinase CKII interacts with and phosphorylates the SAG protein containing ring-H2 finger motif.
PMID: 10230407 by Ohta T., et al. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.