NCOR1 Antibodies

AND NCOR1 ELISA kits, NCOR1 Proteins

Many biological assays use antibodies to detect NCOR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NCOR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NCOR1 antibodies...

We validate the specificity of these antibodies to NCOR1 by testing them on tissues known to express NCOR1 positively and negatively. Browse below to find the NCOR1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NCOR1 Infographic by Boster Bio

All NCOR1 Products

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Specificity

Applications

Price

NCoR1 Colorimetric Cell-Based ELISA Kit

Human, Mouse

ELISA

$480
Cat # EKC1395
1 kit, containing one 96-well plate and all necessary reagents

Anti-N-CoR (H76) NCOR1 Antibody

Human, Mouse, Rat

IF, IHC, WB

$405
Cat # A01304
100ul

Anti-N-CoR NCOR1 Monoclonal Antibody

Human

ELISA, IHC, WB

$380
Cat # M01304
100ul

NCOR1 Overview

Facts about Nuclear receptor corepressor 1.

NCOR1 3D structure. Source: alphafold

Nuclear receptor corepressor 1 (NCOR1)

Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.

Participates in the transcriptional repressor activity made by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).

Gene Information

Human
Gene Name:	NCOR1
Uniprot:	O75376
Entrez:	9611

Family

Belongs to:

N-CoR nuclear receptor corepressors family

Alternative Names

hN-CoR; KIAA1047; KIAA1047N-CoR1; MGC104216; N-CoR; NCOR1; N-CoRhCIT529I10; nuclear receptor corepressor 1; nuclear receptor co-repressor 1; thyroid hormone- and retinoic acid receptor-associated corepressor 1; TRAC1

Molecular Weight

Mass (kDA):
270.21 kDA

Genomic Context


Human

Location:	17p12-p11.2
Sequence:	17; NC_000017.11 (16029157..16216475, complement)

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Breast
Leukemia
Mammary Neoplasms
Carcinoma
Malignant Neoplasm Of Prostate
Myeloid Leukemia
Acute Promyelocytic Leukemia
Malignant Paraganglionic Neoplasm
Leukemia, Myelocytic, Acute
Inflammation
Chromosomal Translocation

Cell Transformation, Neoplastic
Prostatic Neoplasms
Traditional Serrated Adenoma
Hyperplasia
Lymphoma
Leukemogenesis
Pituitary Diseases

Interacting Proteins

DACH1
HDAC3
HTT
NR1D1
NR1H2

NR1H3
PPARA
RARA
RUNX1T1
SKI

TRIM28

Pathways

Cell Cycle
Cell Proliferation
Pathogenesis
Localization
Chromatin Remodeling
Histone Deacetylation
Histone Acetylation
Cell Differentiation
Rna Interference
Chromatin Modification
Cell Growth
Dna Repair
Cell Cycle Arrest

Inflammatory Response
Methylation
Lipid Homeostasis
Oncogenesis
Gene Silencing
Neurogenesis
Regulation Of Gene Expression

PTMs

Acetylation
Phosphorylation
Deacetylation
Sumoylation
Cleavage

Methylation
Demethylation
Oxidation
Ubiquitination
Carboxylation

Myristoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NCOR1

References

PMID: 9724795 by Wang J., et al. ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex.

PMID: 10444336 by Nagaya T., et al. Localization of the human nuclear receptor co-repressor (hN-CoR) gene between the CMT1A and the SMS critical regions of chromosome 17p11.2.