NBR1 Antibodies

Next to BRCA1 gene 1 protein (NBR1)

Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. .

Gene Information

Human
Gene Name:	NBR1
Uniprot:	Q14596
Entrez:	4077

Family

Belongs to:
No superfamily

Alternative Names

Cell migration-inducing gene 19 protein; FLJ98272; KIAA0049CA125; M17S2FLJ55359,1A1-3B; Membrane component chromosome 17 surface marker 2,1A13B; membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigenCA125); migration-inducing protein 19; Neighbor of BRCA1 gene 1 protein; neighbor of BRCA1 gene 1; next to BRCA1 gene 1 protein; Protein 1A1-3B

Molecular Weight

Mass (kDA):
107.413 kDA

Genomic Context

Human
Location:	17q21.31
Sequence:	17; NC_000017.11 (43170310..43211688)

Subcellular Localizations

Cytoplasm. Cytoplasmic vesicle, autophagosome. Lysosome. Cytoplasm, myofibril, sarcomere, M line. In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation (PubMed:19250911).

Diseases

• Malignant Neoplasms
• Ovarian Neoplasm
• Malignant Neoplasm Of Ovary
• Neoplasms
• Carcinoma
• Epithelial Ovarian Cancer
• Malignant Paraganglionic Neoplasm
• Mammary Neoplasms
• Cell Transformation, Neoplastic
• Adenocarcinoma
• Neurodegenerative Disorders
• Atrophy
• Cystadenocarcinoma, Serous

• Neoplasm Metastasis
• Malignant Neoplasm Of Breast
• Myopathy
• Endometriosis, Site Unspecified
• Endometrial Polyp
• Lung Neoplasms
• Pelvic Inflammatory Disease

Interacting Proteins

• GABARAP
• GABARAPL1
• GABARAPL2
• GSK3A
• GSK3B

• HTT
• MAP1LC3A
• MAP1LC3B
• MAP1LC3C
• SQSTM1

• SYT4
• UBC
• USP8

Pathways

• Autophagy
• Localization
• Transport
• Osteoblast Differentiation
• Immune Response
• Cytokinesis
• Macroautophagy
• Programmed Cell Death
• Developmental Process
• Regulation Of Autophagy
• Spermatogenesis
• Translation
• Mrna Transcription

• Cell Cycle
• Innate Immune Response
• Cardiac Myofibril Assembly
• Response To Nutrient
• Catabolic Process
• Endosomal Transport
• Cell Proliferation

PTMs

• Ubiquitination
• Phosphorylation

• Biotinylation
• Cleavage

• Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NBR1

Boster Bio Anti-Next To BRCA1 Gene 1 Protein - Best Uses Of The NBR1 Marker

Boster Bio Anti–Next to BRCA1 gene 1, protein is something you may have heard about. This article will discuss its uses and benefits. This product is very popular in biomedicine and the scientific community. It can also be very useful for specific types research. Its benefits go beyond the detection of BRCA gene genes and cancer research.

Boster Bio Anti-Next to BRCA1 Gene 1 Protein NBR1 Marker

The Boster Bio Anti-Next BRCA1/NRB1Marker is a monoclonal antibodies that can be used for the WB assay. It binds specifically to the NBR1 (a widely expressed protein which binds and ubiquitin-binding protein). This protein also interacts with RNF29, SQSTM1, and USP8. It acts as a cargo adapter to autophagic degrading ubiquitinated substrates. It is believed that the UBA domain of the protein regulates the activity of P62, a protein which is involved as autophagic breakdown of ubiquitinated materials.

Applications

The NBR1 genes encode a protein that recognizes autophagic substances. This protein is essential for autophagy, and its localization to the vacuole is dependent on the core autophagic machinery. Studies have shown SmNBR1 localizes in the vacuole. The NBR1 mark can be used in cancer cells to detect the function or autophagy in various types of tumors.

The NBR1 gene encodes an NBR1 protein that has a high sequence similarity with the NBR1 marker. Its protein contains a CFR which includes three conserved serine residues. GFP-Trap analysis shows that the NBR1 genome encodes a protein of 96kD. GFP-Trap analysis revealed a protein that binds to the autophagy cargo.

The gene encodes an interaction protein for ubiquitin. This protein is needed for the formation and maintenance of endogenous pexosomes in mammals. The NBR1 homolog, which is also important in plant aggrephagy has been implicated with heat stress pexophagy. Peroxisomes, which are responsible b-oxidation fatty acids and biotin synthesizing, are common in fungi. Peroxisomes are also essential for reproductive development as well as homeostasis in reactive oxygen species.

NBR1 also binds to protein aggregates, and is involved in xenophagy. NBR1 is implicated in autophagy and also in ribosome function. It is also involved with ABA signalling. It could be an indicator that the tumour is autophagic by detecting NBR1 overexpression in a tumor.

AtNBR1's function is still unclear. It could act as a receptor for ABA pathway elements. This protein may regulate PP2C phosphatases, which are negative regulators of ABA signalling. However, the data suggest that AtNBR1 is involved in autophagy. Further research is needed to confirm these findings. The NBR1 gene could be used in many ways to treat cancer.

Numerous filamentous Ascomycetes include homologs of NBR1. S.pombe and filamentous acomycetes are distinct clades. In addition, amino acid sequence alignment of these proteins revealed a consensus sequence located at the C-terminus. The SmNBR1 variants that were truncated failed to produce ascospores and didn't cover plates within eight day. The truncated SmNBR1 variants were unable produce fruiting body and ascospores. They also failed to cover plates in mycelium. They also had no LIR motif but were unable produce ascospores or cover plates with mycelium.

The NBR1 gene has been implicated with several processes involving ABA. One such example is ABA signalling. Four-week-old plants expressing AtNBR1 overexpression had a large number of genes (called DEGs). These gene pairs are expressed differently from the NBR1-KO and KO lines. DEGs can be 1.5-fold higher than normal.

Benefits

The NBR1 gene is a potential molecular target for improving tree stress resistance. The transgenic poplars were able to induce the gene's expression, which conferred salt tolerance. Activated selfphagy promotes the breakdown of ubiquitinated as well as insoluble proteins. Activated phytophagy also increases salt tolerance. It is an important molecular target that can improve stress resistance in trees.

NBR1 is produced in sulfur deficiency. The absence of NBR1 does not result in any sulfur deficiency, so a study that over-expresses it will likely have little effect on plant growth. However, NBR1 is a physiological marker. Therefore, NBR1 over-expressed may not have any effect. However, the study does not consider nbr1KO ligands.

Autophagy is an important regulator of NBR1's gene. NBR1 regulates protein cargoes autophagy degradation. NBR1 could also be increased, which may help maintain K+/Na+ balance. Numerous studies have shown NBR1 ovexrepression enhances ribosome remodeling in cancer-cell cells. The benefits of this gene continue to grow.

The PagNBR1 gene also controls the antioxidant system, which is a key component for plant growth. Transgenic poplars carrying PagNBR1 exhibited improved salt stress tolerance. Moreover, over-expression of NBR1 in transgenic lines resulted in the accumulation of autophagosomes. This shows that NBR1 can be used to increase salt tolerance in plants and activate the antioxidant system.

Over-expression of the NBR1 gene increases salt tolerance in transgenic poplars. It promotes the degradation insoluble ubiquitinated protein. Moreover, it promotes SUMOylation of ANXA1, a key regulator for selective autophagy. The NBR1 gene is essential for the selective degradation of IKKa. The NBR1 genes are a valuable tool for research in many fields, including agricultural.

Researchers examined salt tolerance in transgenic poplars using the Lico-6400 Portable Photosynthesis Systems. For four days, 60-day-old plants were given 400 mM NaCl to test the effect. The plants were photographed both before and after treatment. Relative electrical conductivity, MDA content, net CO2 assimilation, stomatal conductance, and Fv/Fm were measured.