NAD(P)H-hydrate epimerase Antibodies

AND NAXE ELISA kits, NAD(P)H-hydrate epimerase Proteins

Many biological assays use antibodies to detect NAD(P)H-hydrate epimerase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NAD(P)H-hydrate epimerase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NAD(P)H-hydrate epimerase antibodies...

We validate the specificity of these antibodies to NAD(P)H-hydrate epimerase by testing them on tissues known to express NAXE positively and negatively. Browse below to find the NAXE antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NAXE Infographic by Boster Bio

All NAXE Products

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Product

Figures

Specificity

Applications

Price

Anti-AIBP NAXE Antibody

7 Q&As

Human, Mouse, Rat

IF, WB

$360
Cat # A10537
100 µl

APOA1BP (NAXE) (NM_144772) Human Over-expression Lysate

Human

$628
Cat # LS128240
100 µg

Anti-NAXE Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A10537-1
100 μg/vial

NAXE Overview

Facts about NAD(P)H-hydrate epimerase.

NAXE 3D structure. Source: alphafold

NAD(P)H-hydrate epimerase (NAXE)

Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to enable the repair of both epimers of NAD(P)HX.

Gene Information

Human
Gene Name:	NAXE
Uniprot:	Q8NCW5
Entrez:	128240

Family

Belongs to:

NnrE/AIBP family

Alternative Names

NAD(P)H-hydrate epimerase

Molecular Weight

Mass (kDA):
31.675 kDA

Genomic Context


Human

Location:	1q22
Sequence:	1; NC_000001.11 (156591776..156599818)

Tissue Specificity

Ubiquitously expressed, with highest levels in kidney, heart and liver. Present in cerebrospinal fluid and urine but not in serum from healthy patients. Present in serum of sepsis patients (at protein level).

Subcellular Localizations

Mitochondrion. Secreted. In sperm, secretion gradually increases during capacitation.

Diseases

Encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy (PEBEL)

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NAXE

References

PMID: 11991719 by Ritter M., et al. Cloning and characterization of a novel apolipoprotein A-I-binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I.

PMID: 27616477 by Kremer L.S., et al. NAXE mutations disrupt the cellular NAD(P)HX repair system and cause a lethal neurometabolic disorder of early childhood.