NAPEPLD Antibodies

AND NAPEPLD ELISA kits, NAPEPLD Proteins

Many biological assays use antibodies to detect NAPEPLD, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NAPEPLD in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NAPEPLD antibodies...

We validate the specificity of these antibodies to NAPEPLD by testing them on tissues known to express NAPEPLD positively and negatively. Browse below to find the NAPEPLD antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NAPEPLD Infographic by Boster Bio

All NAPEPLD Products

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Anti-NAPE PLD (NAPEPLD) Mouse Monoclonal Antibody [Clone ID: OTI5F7]

Human, Mouse, Rat

Flow Cytometry, IF, IHC, WB

$523
Cat # M07504
100 µl

NAPEPLD Overview

Facts about N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D.

NAPEPLD 3D structure. Source: alphafold

N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (NAPEPLD)

Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid (PubMed:25684574, PubMed:14634025, PubMed:16527816). Responsible for the creation of these bioactive fatty acid ethanolamides (FAEs), including anandamide (N-arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (PubMed:14634025).

As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body weight and temperature. Specifically, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose (By similarity).

Gene Information

Human
Gene Name:	NAPEPLD
Uniprot:	Q6IQ20
Entrez:	222236

Family

Belongs to:

NAPE-PLD family

Alternative Names

C7orf18; DKFZp781D1098; EC 3.1.4; EC 3.1.4.-; N-acyl phosphatidylethanolamine phospholipase DNAPE-PLDFMP30; N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; NAPE-hydrolyzing phospholipase D

Molecular Weight

Mass (kDA):
45.596 kDA

Genomic Context


Human

Location:	7q22.1
Sequence:	7; NC_000007.14 (103099576..103149560, complement)

Tissue Specificity

Widely expressed. Highest expression in brain, kidney and testis (at protein level). Expressed in adipose tissue (at protein level).

Subcellular Localizations

Golgi apparatus membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Nucleus envelope. Nucleus, nucleoplasm. Localized in the proximity of the cellular membranes likely through interaction with membrane phospholipids.

Diseases

Obesity
Obesity, Morbid
Inflammation

PTMs

Acetylation

Research Areas

Lipid and Metabolism
Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NAPEPLD

References

PMID: 14634025 by Okamoto Y., et al. Molecular characterization of a phospholipase D generating anandamide and its congeners.

PMID: 15820312 by Curtiss N.P., et al. Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22.