Collagenase 3 Antibodies

AND MMP13 ELISA kits, Collagenase 3 Proteins

Many biological assays use antibodies to detect Collagenase 3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Collagenase 3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Collagenase 3 antibodies...

We validate the specificity of these antibodies to Collagenase 3 by testing them on tissues known to express MMP13 positively and negatively. Browse below to find the MMP13 antibody that suites your experiment. We have 8 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MMP13 Infographic by Boster Bio

All MMP13 Products

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Specificity

Applications

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Human MMP13/Collagenase 3 ELISA Kit PicoKine®

29 Citations 4 Q&As

Human

ELISA

$499
Cat # EK0468
96 wells/kit, with removable strips.

Anti-MMP13 Antibody Picoband®

5 Citations 15 Q&As

Human, Monkey

$370
Cat # A00420
100 μg/vial

Anti-MMP13 Rabbit Monoclonal Antibody

4 Citations 15 Q&As

Human, Mouse

$370
Cat # M00420
100 μl

Anti-MMP13 Antibody Picoband®

16 Citations 16 Q&As

Human, Mouse, Rat

ELISA, IHC, WB

$370
Cat # A00420-2
100 μg/vial

Anti-MMP-13 Antibody

1 Citations

Human, Mouse

Flow Cytometry, IF, IHC, ICC, WB

$405
Cat # A00420-1
100ul

Human MMP-13 Recombinant Protein

SDS-PAGE

$281
Cat # PROTP45452
Starting from 10ug

Anti-MMP13 Mouse Monoclonal Antibody [Clone ID: OTI2D8]

Human, Mouse, Rat

IF, IHC, WB

$523
Cat # M00420-1
100 µl

Anti-MMP13 Antibody Picoband®

3 Citations

Human

ELISA, WB

$370
Cat # A00420-3
100 μg/vial

MMP13 Overview

Facts about Collagenase 3.

MMP13 3D structure. Source: alphafold

Collagenase 3 (MMP13)

Plays a role in the degradation of extracellular matrix proteins such as fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen.

Can also degrade collagen type IV, type XIV and kind X. May also be the activating or degrading key regulatory proteins, such as TGFB1 and CTGF.

Gene Information

Human
Gene Name:	MMP13
Uniprot:	P45452
Entrez:	4322

Family

Belongs to:

peptidase M10A family

Alternative Names

CLG 3; CLG3EC 3.4.24; collagenase 3; EC 3.4.24.-; EC 3.4.24.22; EC 3.4.24.24; EC 3.4.24.35; EC 3.4.24.65; EC 3.4.24.7; MANDP1; matrix metallopeptidase 13 (collagenase 3); matrix metalloproteinase 13 (collagenase 3); Matrix metalloproteinase-13; MMP13; MMP-13

Molecular Weight

Mass (kDA):
53.82 kDA

Genomic Context


Human

Location:	11q22.2
Sequence:	11; NC_000011.10 (102942995..102955732, complement)

Tissue Specificity

Detected in fetal cartilage and calvaria, in chondrocytes of hypertrophic cartilage in vertebrae and in the dorsal end of ribs undergoing ossification, as well as in osteoblasts and periosteal cells below the inner periosteal region of ossified ribs. Detected in chondrocytes from in joint cartilage that have been treated with TNF and IL1B, but not in untreated chondrocytes. Detected in T lymphocytes. Detected in breast carcinoma tissue.

Subcellular Localizations

Secreted, extracellular space, extracellular matrix. Secreted.

Diseases

Degenerative Polyarthritis
Neoplasms
Malignant Neoplasms
Inflammation
Arthritis
Cell Invasion
Carcinoma
Hypertrophy
Neoplasm Metastasis
Fibrosis
Rheumatoid Arthritis
Neoplasm Invasiveness
Tumor Angiogenesis

Malignant Paraganglionic Neoplasm
Malignant Squamous Cell Neoplasm
Malignant Neoplasm Of Breast
Hepatic Fibrosis
Osteoarthritis, Knee
Pathologic Neovascularization
Mammary Neoplasms

Pathways

Pathogenesis
Ossification
Angiogenesis
Secretion
Cell Migration
Bone Resorption
Endochondral Ossification
Cell Proliferation
Bone Remodeling
Wound Healing
Tissue Remodeling
Localization
Chondrocyte Differentiation

Proteolysis
Regeneration
Inflammatory Response
Aging
Chondrocyte Hypertrophy
Reverse Transcription
Osteoblast Differentiation

PTMs

Cleavage
Phosphorylation
Methylation
Demethylation
Acetylation
Hydroxylation
Biotinylation
Glycosylation
Oxidation
Sulphation

Sumoylation
Nitrosylation
Carboxylation
Phosphorothioation
Amidation
Citrullination
Iodination
Nitration
Reduction
Farnesylation

Research Areas

Cancer
Cellular Markers
Extracellular Matrix

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MMP13

References

PMID: 8207000 by Freije J.M.P., et al. Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas.

PMID: 9562863 by Willmroth F., et al. A matrix metalloproteinase gene expressed in human T lymphocytes is identical with collagenase 3 from breast carcinomas.

47 Publications of Boster Collagenase 3 Antibodies & ELISA Kits

PubMed ID: PMID:33594314, Allogeneic adipose-derived mesenchymal stem cells promote the expression of chon...
PubMed ID: PMID:30018711, HOXB5 promotes retinoblastoma cell migration and invasion via ERK1/2 pathway-med...
PubMed ID: 10.3892/ijmm.2017.2885, Resveratrol inhibits the IL-1β-induced expression of MMP-13 and IL-6 in human a...
PubMed ID: 10.3892/ijmm.2015.2183, Hydrogen sulfide attenuates IL-1β-induced inflammatory signaling and dysfunctio...
PubMed ID: 10.3390/ijms22168980, A Combination of Celecoxib and Glucosamine Sulfate Has Anti-Inflammatory and Cho...
PubMed ID: 10.3233/THC-191811, Elevated synovial fluid IL-33 and IL-6 levels and cartilage degeneration in stag...
PubMed ID: 10.1186/s12885-021-08566-1, Serum matrix metalloproteinase-13 as a diagnostic biomarker for cutaneous squamo...
PubMed ID: 10.1080/07315724.2015.1068139, Effects of l-Carnitine Supplementation on Serum Inflammatory Factors and Matrix...
PubMed ID: 10.1039/D1BM00743B, Carbazate modified cross- linked dextran microparticles suppress the progression...
PubMed ID: 10.1038/srep21190, Heme oxygenase-1 attenuates IL-1β induced alteration of anabolic and catabolic ...
PubMed ID: 10.1016/S1995-7645(14)60097-3, Effect of Rougan Huaqian granules combined with human mesenchymal stem cell tran...
PubMed ID: 10.1016/j.phymed.2017.10.016, Anti-inflammatory and anti-arthritic effects of the ethanolic extract of Aralia ...
PubMed ID: 10.1016/j.livsci.2021.104568, Dietary supplementation with Celecoxib to prevent the welfare problem of tibial ...
PubMed ID: 10.1016/j.intimp.2020.106657, Sodium butyrate protects against oxidative stress in human nucleus pulposus cell...
PubMed ID: 10.1016/j.intimp.2018.10.004, Methylsulfonylmethane and mobilee prevent negative effect of IL-1β in human cho...
PubMed ID: 10.1016/j.intimp.2016.07.002, Dopamine D2 receptor suppresses gastric cancer cell invasion and migration via i...
PubMed ID: 10.1016/j.freeradbiomed.2017.02.041, Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and cho...
PubMed ID: 10.1007/s10238-011-0131-z, Enhancement of subchondral bone quality by alendronate administration for the re...
PubMed ID: 10.1002/jgm.1009, Modified synthetic siRNA targeting tissue inhibitor of metalloproteinase‐2 inh...
PubMed ID: 10.1002/jcb.28098, Carvacrol suppresses inflammatory responses in rheumatoid arthritis fibroblast�...
PubMed ID: , Cartilage-targeting and dual MMP-13/pH responsive theranostic nanoprobes for ost...

*Showing only the more recent 20. More publications can be found for each product on its corresponding product page