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- Table of Contents
Facts about Mixed lineage kinase domain-like protein.
Does not have protein kinase activity. .
Mouse | |
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Gene Name: | Mlkl |
Uniprot: | Q9D2Y4 |
Entrez: | 74568 |
Belongs to: |
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protein kinase superfamily |
FLJ34389; mixed lineage kinase domain-like protein; mixed lineage kinase domain-like; MLKL
Mass (kDA):
54.317 kDA
Mouse | |
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Location: | 8|8 E1 |
Sequence: | 8; |
Highly expressed in thymus, colon, intestine, liver, spleen and lung. Expressed at much lower level in skeletal muscle, heart and kidney. Not detected in brain.
PMID: 22265413 by Sun L., et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase.
PMID: 23835476 by Wu J., et al. Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis.