MTUS1 Antibodies

Microtubule-associated tumor suppressor 1 (MTUS1)

Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be necessary for AGTR2 cell surface expression.

Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell regeneration, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.

Gene Information

Human
Gene Name:	MTUS1
Uniprot:	Q9ULD2
Entrez:	57509

Family

Belongs to:
MTUS1 family

Alternative Names

Angiotensin-II type 2 receptor-interacting protein; AT2 receptor-binding protein; AT2R binding protein; ATBPATIP1; ATIP; DKFZp586D1519; erythroid differentiation-related; FLJ14295; GK1; KIAA1288DKFZp686F20243; microtubule associated tumor suppressor 1; microtubule-associated tumor suppressor 1; Mitochondrial tumor suppressor 1; mitochondrial tumor suppressor gene 1; MP44; MTSG1AT2 receptor-interacting protein; transcription factor MTSG1

Molecular Weight

Mass (kDA):
141.397 kDA

Genomic Context

Human
Location:	8p22
Sequence:	8; NC_000008.11 (17643794..17801579, complement)

Tissue Specificity

Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain- specific, it is the major isoform in cerebellum and fetal brain.

Subcellular Localizations

Mitochondrion. Golgi apparatus. Cell membrane. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin-II.; [Isoform 1]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis.

Diseases

• Neoplasms
• Malignant Neoplasms
• Carcinoma
• Carcinogenesis
• Malignant Neoplasm Of Breast
• Mammary Neoplasms
• Colonic Neoplasms
• Hyperplasia
• Malignant Tumor Of Colon
• Malignant Paraganglionic Neoplasm
• Cardiovascular Diseases
• Colorectal Cancer

• Cytogenetic Abnormality
• Cell Transformation, Neoplastic
• Malignant Squamous Cell Neoplasm
• Neoplasm Metastasis
• Adenoma
• Cardiac Hypertrophy
• Neoplasm Invasiveness

Pathways

• Cell Proliferation
• Cell Growth
• Methylation
• Cell Division
• Negative Regulation Of Protein Kinase Activity
• Regulation Of Protein Kinase Activity
• Mitosis
• Dedifferentiation

• Metaphase
• Wound Healing
• Localization

PTMs

• Phosphorylation

Research Areas

• Breast Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MTUS1

Boster Bio - The Best Uses Of The MTUS1 Marker

This article will cover Boster Bio’s high affinity primary antibodies against the MTUS1 marker. It also discusses Targets, Cost, and Other Information. This article will explain what MTUS1 means and why Boster is an excellent choice to support your research. You'll also learn about the Boster Bio workflow. It's quite simple: we'll walk with you through the MTUS1 goal, what it means to your research, and how Boster’s MTUS1 antibody operates.

Boster provides high-affinity primary antibodies

Boster Bio has launched a new product that provides high-affinity primary antibodies against LTUS1 to enhance the performance of your reagents. The marker lies within the B region of the chicken MHC and has been associated with serology. In addition to its importance in serology, this marker has also been shown to correlate with MHC class I and II alleles.

MTUS1

The MTUS1 markers in Boster Bio are best for identifying MT-associated proteins. These proteins include MAP7 and NAP1L1, ANK2, MAP9 and MTUS1. These antibodies are essential for various research applications. Boster's antibodies are highly specific and validated for use in ELISA, WB, and immunohistochemistry.

Targets

The MTUS1 genetic mutation can be found on a wide range of animals, including primates and humans. Multi-component viruses, unlike other viruses, deliver their genome by releasing individual parts from the cell's surface. Although this is counter-intuitive, it is possible for such viruses to leap into humans. Their presence within the animal kingdom has implications on human health. Further research is required to understand their evolutionary drive.

Cost

The MTUS1 genes is expressed in the breast, testes and prostate. The cost of this marker varies between $2000 and $10,000. In this study, the MTUS1 gene was expressed in ccRCC cell lines and transwell assays. The optimal cutoff was calculated. The formula used to calculate the cutoff. The MTUS1 marker cost was compared against the price of the other tests.

MTUS1 is a tumor suppressor protein. Different types are associated with different amounts. In GBC, it is thought to have a tumor-suppressive function. The MTUS1 gene is a promising biomarker to diagnose breast cancer. The cost of this marker is still a problem. It may not be affordable for everyone. It is an important part in evaluating a patient’s prognosis.

The MTUS1 gene is located on chromosome 8p22 and contains 17 exons. A poor prognosis and poor survival rate are associated with loss of the gene. Metastasis is possible when MTUS1 is lost. Breast cancer cells with MTUS1 deletion show higher invasiveness and decreased survival.

There are many benefits to using the MTUS1 gene for SACC biomarkers. This marker can help monitor tumor progression, and may also be used to develop new treatments. The patient's insurance coverage will determine the cost of MTUS1. In addition to its role as a biomarker, it is a potential therapeutic target. SACC tissue contains the MTUS1 gene, which regulates its growth, migration, invasion, and other functions.