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Protein LYRIC Antibodies
AND Mtdh ELISA kits, Protein LYRIC Proteins
Many biological assays use antibodies to detect Protein LYRIC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein LYRIC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein LYRIC antibodies...
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Mtdh Infographic by Boster Bio
All Mtdh Products
Product
Figures
Specificity
Applications
Price
Anti-LYRIC/MTDH Antibody Picoband®
1 Citations 1 Q&As
Human, Mouse, Rat
IHC, ICC, WB
$370
Cat # PB9338
100 μg/vial
Cat # PB9338
100 μg/vial
Human
ELISA, Flow Cytometry, IHC, WB
$380
Cat # M04060-1
100ul
Cat # M04060-1
100ul
Human
Flow Cytometry, IHC, WB
$370
Cat # M04060-2
100 μg/vial
Cat # M04060-2
100 μg/vial
Mtdh Overview
Facts about Protein LYRIC.
Protein LYRIC (Mtdh)
Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF- kappa-B) transcription factor.
Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an impact on bone and brain metastasis, possibly by enhancing the seeding of tumor cells into the target organ endothelium.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Mtdh |
| Uniprot: | Q80WJ7 |
| Entrez: | 67154 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
3D3; AEG1; AEG-13D3/LYRIC; AEG1LYRIC/3D3; Astrocyte elevated gene-1 protein; LYRIC; LYRICMetastasis adhesion protein; Lysine-rich CEACAM1 co-isolated protein; Metadherin; MTDH; protein LYRIC
Molecular Weight
Mass (kDA):
63.846 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 15 B3.1|15 13.98 cM |
| Sequence: | 15; |
Tissue Specificity
In the mammary gland, expressed at the apical surface of epithelial cells lining ducts, as well as in the mammary fat pad. Not detected in the spleen, kidney, lung, or skin; minute amounts seen in the liver. Expressed in Purkinje neurons in the early postnatal and adult cerebellum. Overexpressed in mammary tumors (at protein level).
Diseases
- Malignant Neoplasms
- Neoplasms
- Neoplasm Metastasis
- Cell Invasion
- Carcinoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Tumor Progression
- Neoplasm Invasiveness
- Malignant Paraganglionic Neoplasm
- Carcinogenesis
Pathways
- Cell Proliferation
- Angiogenesis
- Pathogenesis
- Cell Growth
- Oncogenesis
- Localization
- Cell Cycle
- Translation
- Cell Death
- Cell Migration
- Senescence
- Drug Resistance
- Rna Interference
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Mtdh
bosterbio.com/bosterbio-gene-info-cards/Mtdh
References
PMID: 15093543 by Brown D.M., et al. Metadherin, a cell surface protein in breast tumors that mediates lung metastasis.
PMID: 14980505 by Sutherland H.G.E., et al. 3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus.
1 Publications of Boster Protein LYRIC Antibodies & ELISA Kits
- PubMed ID: 10.1111/1440-1681.12767, Silencing of astrocyte elevated gene‐1 inhibits proliferation and migration of...
*More publications can be found for each product on its corresponding product page