MTA2 Antibodies

Metastasis-associated protein MTA2 (MTA2)

May be involved in the regulation of gene expression as repressor and activator. The repression may be associated with covalent modification of histone proteins.

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Gene Information

Human
Gene Name:	MTA2
Uniprot:	O94776
Entrez:	9219

Family

Belongs to:
No superfamily

Alternative Names

DKFZp686F2281; metastasis associated 1 family, member 2; metastasis -associated gene 1-like 1; metastasis associated gene family, member 2; Metastasis-associated 1-like 1; metastasis-associated protein 2; metastasis-associated protein MTA2; MTA1-L1 protein; MTA1L1MTA1-L1; p53 target protein in deacetylase complex; PID

Molecular Weight

Mass (kDA):
75.023 kDA

Genomic Context

Human
Location:	11q12.3
Sequence:	11; NC_000011.10 (62593214..62601865, complement)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Nucleus.

Diseases

• Neoplasm Metastasis
• Neoplasms
• Malignant Neoplasms
• Malignant Neoplasm Of Breast
• Mammary Neoplasms
• Cell Invasion
• Carcinoma
• Metastatic Malignant Neoplasm To The Lymph Node
• Neoplasm Invasiveness
• Malignant Paraganglionic Neoplasm
• Growth Arrest
• Cell Transformation, Neoplastic
• Lung Neoplasms

• Non-small Cell Lung Carcinoma
• Inflammation
• Tumor Progression
• Malignant Neoplasm Of Lung
• Epithelial Ovarian Cancer
• Ovarian Neoplasm
• Precancerous Conditions

Interacting Proteins

• EHMT2
• HDAC1
• PARK7
• RBBP7
• ZEB2

• ZNF827

Pathways

• Chromatin Remodeling
• Localization
• Histone Deacetylation
• Cell Proliferation
• Dna Methylation
• Methylation
• Dna Replication
• Rna Interference
• Cell Adhesion
• Cell Cycle
• Histone Acetylation
• Cell Growth
• Pathogenesis

• Cell Activation
• Atp-dependent Chromatin Remodeling
• Cell Migration
• Gene Silencing
• T Cell Activation
• Mammary Gland Morphogenesis
• Immune Response

PTMs

• Deacetylation
• Acetylation
• Methylation

• Phosphorylation
• Biotinylation
• Phosphorothioation

Research Areas

• Cancer
• Chromatin Research
• Transcription Factors and Regulators
• Tumor Suppressors

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MTA2

Steven Boster Bio - Best Uses Of The MTA2 Marker

In this Steven Boster bio we will discuss his history, career, and favorite MTA2 markers. We'll also be discussing some of his favorite uses. Let's go! I'm sure you are curious about Steven Boster. Let's begin! This article will give you some background information about the artist and his favorite uses for the MTA2 marker.

Steven Boster's history

His fascinating history is told by Steve Boster. He was the son and daughter of Evelyn Meier (James Boster) and had a long and successful career in retail sales. He was also a U.S. Army veteran. He was also a member of Concordia Hall in Staunton, VA, and is survived by his wife Natosha Peck, 2 daughters, Crystal Boster and Jonathan Boster, 6 grandchildren, and 4 brothers, Jack, Sandy, and David. He also left behind many nieces and nephews.

Steve established his company in 1993. Steve quickly gained a solid reputation for developing products for immunohistochemistry. His most notable accomplishments were the development of hundreds if not thousands of primary antibodies. These included monoclonal antibodies in mice, rat and goat, as well as heparin. This helped Boster become the largest catalog antibody company in China by the late 1990s. Steven Boster's success lead to the creation of PicoKine(tm), a proprietary ELISA system that allowed for the delivery of a wide range high-sensitivity ELISA products.

Favorite MTA2 Markers

Favourite MTA2 markers are those containing the most amino acids. Numerous studies have shown that the MTA2 marker is highly expressed within ES cells. It is not clear how Sall1 or Sall4 interact. Many proteins with variable N termini could interact with MTA complexes. These proteins include Zfp423 (Ebfaz), Sall1/2/3/4, and Fog1/2. They also interact via their Ntermini.

MTA2 makes up part of the NuRD Complex, which regulates gene activity and remolds nucleosomes. It also participates in cell migration and control the cytoskeleton. However, despite its numerous functions, scientists are unsure why it is important to study MTA2 in patients with gastric cancer. MTA2 plays a critical role in controlling the expressions of NuRD.

Career

The Human Protein Atlas has a great image of the MTA2 Marker. It is highly expressed in HCC cells' nuclei. The Cancer Genome Atlas analysis showed that HCC also showed an increase in MTA2 expression. HCC has a high level of MTA2 which is associated with poor overall survival and disease-free survival. MTA2 may also be a sign of progression in HCC.