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- Table of Contents
Facts about NADH-ubiquinone oxidoreductase chain 4.
The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). .
Human | |
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Gene Name: | MT-ND4 |
Uniprot: | P03905 |
Entrez: |
Belongs to: |
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complex I subunit 4 family |
ND4
Mass (kDA):
51.581 kDA
Human | |
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Location: | |
Sequence: | ; |
Mitochondrion membrane; Multi-pass membrane protein.
Microglial clusters 2 and 19 are two markers that we will look at in this article. GO analysis is a useful tool for understanding these proteins. We will also discuss how these markers are used in GO analysis. We will also discuss the potential use of these markers in future research. So, what is the best use of this marker? Continue reading for more information. Listed below are some of the best uses of this marker.
The MT-ND4 gene contains instructions for the production and use of the NADH dehydrogenase 4. This protein is a part of the complex-I enzyme complex. It is active inside the mitochondria, structures found in cells that transform food into energy. The enzyme uses oxygen to produce ATP (the cell's main source of energy). MT-ND4 can be found in many tissues and organs, including liver and brain.
Every human cell contains the MT-ND4 gene, which is necessary for the synthesis and maintenance of DNA. To produce mtDNA molecules it needs wild-type copy number MT-ND4. The wild-type copy numbers were significantly lower in patients with respiratory system deficiencies, as shown by this study. MT–ND4 is used in this study to determine the relative levels for the three components of a respiratory chain.
The molecular characteristics of microglial clusters are different. Cluster 2 contained MT–ND4 gene activity. This was linked to proinflammatory hallmark activation genes and M1-like phenotypes. This gene expression was also associated with pathways involved in the inflammatory response and chemotaxis. The findings suggest that this gene expression is useful for identifying inflammatory-related tumors and identifying their progression.
In this study, researchers identified three gene-sequences that identify the MT-ND4 gene. These gene-sequencing studies were performed in the laboratories of Professors Couvreur and Michael P. Ahsan, Muhammad H. and Van B.J. Hwang. Researchers from the University of Pennsylvania also provided data on the MT–ND4 gene expression within microglial clusters 2 through 19 of the brain.
To identify microglial cell that express the MTND4 genes, the MTND4 genome-sequencing technology was created. Researchers have discovered that the MT-ND4 protein is a key molecule in microglial cells.
Wuhan Boster Biological Technology, Ltd. made this antibody. The company has experience in the manufacturing of ELISA tests for biomarkers. Boster Biologicals has products that are compatible with Western blot, IHC, and Western blot. The company's immunological solutions are available through Tebu Bio.
Boster Bio's GO analysis allows you to identify which proteins are involved with various biological processes. This information is essential in understanding the roles of specific genes and their functions in various human diseases. All antibodies that are validated in Boster Bio have been tested for their efficiency on IHC and WB. Some antibodies may react poorly to certain conditions. Boster has solutions for common problems. The troubleshooting manuals can be used as quick reference guides or primers by scientists new to GO analysis.
Boster Bio's primary antibodies have been validated across multiple platforms. They are also high-affinity. This eliminates common errors and ensures high-quality experiments. Additionally, you will receive high-quality, recombinant proteins to support your studies. Boster Bio has the antibody you need. Boster Bio's antibodies are made in large quantities, which is a significant advantage.
PMID: 7219534 by Anderson S., et al. Sequence and organization of the human mitochondrial genome.
PMID: 1377597 by Lu X., et al. Differentiation of HT-29 human colonic adenocarcinoma cells correlates with increased expression of mitochondrial RNA: effects of trehalose on cell growth and maturation.