MSL2 Antibodies

E3 ubiquitin-protein ligase MSL2 (MSL2)

Component of histone acetyltransferase complex responsible for nearly all histone H4 acetylation at lysine 16 which is implicated in the creation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B in'Lys-35' (H2BK34Ub), but not that of H2A.

This action is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation in'Lys-4' (H3K4me) and'Lys-79' (H3K79me) and results in gene activation, such as that of HOXA9 and MEIS1.

Gene Information

Human
Gene Name:	MSL2
Uniprot:	Q9HCI7
Entrez:	55167

Family

Belongs to:
MSL2 family

Alternative Names

FLJ10546; KIAA1585FLJ54913; male-specific lethal 2 homolog (Drosophila); male-specific lethal 2 homolog; male-specific lethal 2-like 1 (Drosophila); Male-specific lethal 2-like 1; Male-specific lethal-2 homolog 1; MSL-2; MSL2L1; MSL2-like 1; PHNPCC4; PMS2; RING finger protein 184msl-2; RNF184

Molecular Weight

Mass (kDA):
62.541 kDA

Genomic Context

Human
Location:	3q22.3
Sequence:	3; NC_000003.12 (136148917..136197300, complement)

Diseases

• Multiple Organ Failure
• Monosomy
• Cell Transformation, Neoplastic
• Tense
• Epithelial Ovarian Cancer
• Ovarian Neoplasm

• Carcinoma

Pathways

• Dosage Compensation
• Localization
• Methylation
• Translation
• Rna Interference
• Transport
• Chromosome Localization
• Photosynthesis
• Proteolysis
• Nuclear Export
• Cell Cycle Arrest
• Cellular Response To Osmotic Stress
• Response To Osmotic Stress

• Histone H4 Acetylation
• Dna Replication
• Protein Complex Assembly
• Membrane Depolarization
• Cell Cycle
• Histone Acetylation
• Interphase

PTMs

• Acetylation

• Methylation

• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MSL2

Boster Bio: Best Uses Of The MSL2 Marker

This article provides a basic understanding about the MSL2 protein and the primary antibodies most commonly cited by the research community. It also includes gene infographics and background information from Boster Bio. The end result is an overview of the MSL2 marker and its best uses for various biological research. You can learn more about Steven Boster by reading the rest of this article.

Boster's primary antibodies are highly-cited in the research community

Boster’s primary antibodies are highly-cited due to their high affinity. They are well-validated and have been used for decades by researchers around the world. These antibodies have been validated for use in Western Blotting, Immunohistochemistry, and ELISA. These antibodies are useful in helping scientists understand and control diseases in a variety cell types. By focusing on primary antibodies, Boster provides scientists with a high-quality and reliable source of reagents that are essential for research.

ANTIHUMAN MAC-2, the most frequently cited Boster antibody, is also a highly cited one in the research community. This antibody is an anti DNA/RNA hybrid. It is used to study breast cancer. Another example is Anti-Mouse GAL-63 antibodies, which are used to study breast-cancer. Lastly, there is Anti-Puromycin, which is an anti-virus.

Steven Boster's past

Steven Boster, The Wizard of Oz's protagonist, is presented as a boy who likes adventure in his debut feature film. Steven, despite his boyish appearance, is very naive. Steven has never been to high school or had his vitals checked. Steven is always up for an adventure but his impulsive nature means he eats more than he can chew. The Homeworld gems save the day.

Steven's Gem abilities are a combination of the Gem and human sides of his family. Although he does not possess pure Gem abilities, he can use Gem magic to his advantage. His gemstone is associated with maternal powers, and is controlled by emotional clearness. These attributes make him an excellent shield fighter. Steven's skills at shield fighting are improving with each practice. He is still able to perform many magical and physical tricks, despite his limitations.

Steven's mental health has declined since his return from Homeworld. In an attempt to help everyone, he interferes in many things, which turns into chaos. In the end, Steven finally lets all of the evil that he learned at Little Homeschool out. Steven, in an emotional meltdown denounces himself to be a monster. After this, he becomes a monster. However, he still attempts to resolve his problems with his friends and family.

As an immature human, Steven possesses the traits of an over-eager child. He is courageous, caring, and quick-witted, but his inexperience and immaturity led him to make mistakes and aggravate the situation. However, his insecurity grew as he matured, but his passion never seemed to stop. Steven's impulsiveness made him an easy target for manipulators. Steven was often misidentified as his mother in his early years, making him vulnerable for manipulation.

Steven has never met Rose in real life, but his feelings for Rose remain complicated. Rose Quartzes is the first person he meets. He still feels guilty for Rose's death, despite her absence. This guilt is temperated by his resentment for Rose's misdeeds. Steven is feeling heavy because Rose's funeral has placed a burden on him. He resents the fact his mother's legacy is now part and parcel of him.

Connie is Steven's childhood friend. She comforts Steven when he is ruminating and moping about his mission's failure. She stays with him as he uses his psychic powers and returns to Earth. She also watches over his body. Just before Steven returns, she falls asleep in her lap with Steven. Steven becomes more powerful as he discovers the truth and his personality grows.

The film also highlights Greg's life. Steven becomes disillusioned when he learns about Greg's past. His parents didn't support him or allow him to pursue his interests, and he eventually runs away to control his destiny. Steven also feels resentful about the lack of experiences he had growing up. He concludes that his lack a normal life has made it difficult for him to cope with the trauma and pain he experienced as a child.