MSL2 Antibodies

AND MSL2 ELISA kits, MSL2 Proteins

Many biological assays use antibodies to detect MSL2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MSL2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MSL2 antibodies...

We validate the specificity of these antibodies to MSL2 by testing them on tissues known to express MSL2 positively and negatively. Browse below to find the MSL2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MSL2 Infographic by Boster Bio

All MSL2 Products

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Product

Figures

Specificity

Applications

Price

Anti-MSL2L1 (MSL2) Mouse Monoclonal Antibody [Clone ID: OTI4G7]

Human, Mouse, Rat

$523
Cat # M02712
100 µl

Anti-MSL2 Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A02712-1
100 μg/vial

MSL2L1 (MSL2) (NM_018133) Human Over-expression Lysate

Human

$628
Cat # LS055167
100 µg

MSL2 Overview

Facts about E3 ubiquitin-protein ligase MSL2.

MSL2 3D structure. Source: alphafold

E3 ubiquitin-protein ligase MSL2 (MSL2)

Component of histone acetyltransferase complex responsible for nearly all histone H4 acetylation at lysine 16 which is implicated in the creation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B in'Lys-35' (H2BK34Ub), but not that of H2A.

This action is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation in'Lys-4' (H3K4me) and'Lys-79' (H3K79me) and results in gene activation, such as that of HOXA9 and MEIS1.

Gene Information

Human
Gene Name:	MSL2
Uniprot:	Q9HCI7
Entrez:	55167

Family

Belongs to:

MSL2 family

Alternative Names

FLJ10546; KIAA1585FLJ54913; male-specific lethal 2 homolog (Drosophila); male-specific lethal 2 homolog; male-specific lethal 2-like 1 (Drosophila); Male-specific lethal 2-like 1; Male-specific lethal-2 homolog 1; MSL-2; MSL2L1; MSL2-like 1; PHNPCC4; PMS2; RING finger protein 184msl-2; RNF184

Molecular Weight

Mass (kDA):
62.541 kDA

Genomic Context


Human

Location:	3q22.3
Sequence:	3; NC_000003.12 (136148917..136197300, complement)

Diseases

Multiple Organ Failure
Monosomy
Cell Transformation, Neoplastic
Tense
Epithelial Ovarian Cancer
Ovarian Neoplasm

Carcinoma

Pathways

Dosage Compensation
Localization
Methylation
Translation
Rna Interference
Transport
Chromosome Localization
Photosynthesis
Proteolysis
Nuclear Export
Cell Cycle Arrest
Cellular Response To Osmotic Stress
Response To Osmotic Stress

Histone H4 Acetylation
Dna Replication
Protein Complex Assembly
Membrane Depolarization
Cell Cycle
Histone Acetylation
Interphase

PTMs

Acetylation

Methylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MSL2

References

PMID: 16227571 by Smith E.R., et al. A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16.

PMID: 16543150 by Mendjan S., et al. Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila.