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- Table of Contents
Facts about Peptidyl-tRNA hydrolase ICT1, mitochondrial.
May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. .
Human | |
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Gene Name: | MRPL58 |
Uniprot: | Q14197 |
Entrez: | 3396 |
Belongs to: |
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prokaryotic/mitochondrial release factor family |
Digestion substraction 1; DS-1DS1; EC 3.1.1.29; Immature colon carcinoma transcript 1 protein; immature colon carcinoma transcript 1; peptidyl-tRNA hydrolase ICT1, mitochondrial
Mass (kDA):
23.63 kDA
Human | |
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Location: | 17q25.1 |
Sequence: | 17; NC_000017.11 (75012670..75021261) |
Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells.
Mitochondrion.
PMID: 8575443 by van Belzen N., et al. Identification of mRNAs that show modulated expression during colon carcinoma cell differentiation.
PMID: 20186120 by Richter R., et al. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome.