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- Table of Contents
, No Gclids
ID3 Antibodies
AND ID3 ELISA kits, ID3 Proteins
Many biological assays use antibodies to detect ID3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ID3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ID3 antibodies...
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ID3 Infographic by Boster Bio
All ID3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M01379
100 µl
Cat # M01379
100 µl
ID3 Overview
Facts about DNA-binding protein inhibitor ID-3.
DNA-binding protein inhibitor ID-3 (ID3)
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the simple helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating many different cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation.
Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and boosting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer.
Gene Information
| Human | |
|---|---|
| Gene Name: | ID3 |
| Uniprot: | Q02535 |
| Entrez: | 3399 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BHLHB25; bHLHb251R21; Class B basic helix-loop-helix protein 25; DNA-binding protein inhibitor ID-3; HEIR1; HEIR-1; Helix-loop-helix protein HEIR-1; ID-like protein inhibitor HLH 1R21; Inhibitor of DNA binding 3; inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
Molecular Weight
Mass (kDA):
12.999 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.12 |
| Sequence: | 1; NC_000001.11 (23557926..23559501, complement) |
Tissue Specificity
Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain.
Subcellular Localizations
Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Lymphohistiocytosis, Hemophagocytic
- Tumor Angiogenesis
- Pathologic Neovascularization
- Hyperplasia
- Malignant Paraganglionic Neoplasm
- Cell Transformation, Neoplastic
- Lymphoma
- Nervousness
- Crest Syndrome
- Neoplasm Metastasis
- Carcinogenesis
Interacting Proteins
- FAM74A1
- TCF12
- TCF3
- TCF4
Pathways
- Cell Proliferation
- Cell Differentiation
- Cell Cycle
- Cell Growth
- Angiogenesis
- Cell Development
- Pathogenesis
- Localization
- Neurogenesis
- Rna Interference
- S Phase
- Cell Cycle Arrest
- Cell Death
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Ubiquitination
Research Areas
- Cancer
- Cell Cycle and Replication
- Prostate Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ID3
bosterbio.com/bosterbio-gene-info-cards/ID3
References
PMID: 1628620 by Ellmeier W., et al. Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development.
PMID: 8437843 by Deed R.W., et al. An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types.