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- Table of Contents
Facts about Mas-related G-protein coupled receptor member X4.
May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).
Human | |
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Gene Name: | MRGPRX4 |
Uniprot: | Q96LA9 |
Entrez: | 117196 |
Belongs to: |
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G-protein coupled receptor 1 family |
G protein-coupled receptor SNSR5; G protein-coupled receptor SNSR6; GPCR; MAS-related GPR, member X4; mas-related G-protein coupled receptor member X4; MGC129753; MGC129754; MRGPRX4; MRGX4; MRGX4G protein-coupled receptor MRGX4; Sensory neuron-specific G-protein coupled receptor 5/6; SNSR5; SNSR6
Mass (kDA):
36.461 kDA
Human | |
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Location: | 11p15.1 |
Sequence: | 11; NC_000011.10 (18172837..18174280) |
Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
Cell membrane; Multi-pass membrane protein.
PMID: 11551509 by Dong X., et al. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons.
PMID: 11850634 by Lembo P.M.C., et al. Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs.