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C-type mannose receptor 2 Antibodies
AND MRC2 ELISA kits, C-type mannose receptor 2 Proteins
Many biological assays use antibodies to detect C-type mannose receptor 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with C-type mannose receptor 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop C-type mannose receptor 2 antibodies...
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MRC2 Infographic by Boster Bio
All MRC2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$523
Cat # M04070
100 µl
Cat # M04070
100 µl
MRC2 Overview
Facts about C-type mannose receptor 2.
C-type mannose receptor 2 (MRC2)
May play a role as endocytotic lectin receptor demonstrating calcium-dependent lectin activity. Internalizes glycosylated ligands in the extracellular area for release in an endosomal compartment through clathrin-mediated endocytosis.
May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices.
Gene Information
| Human | |
|---|---|
| Gene Name: | MRC2 |
| Uniprot: | Q9UBG0 |
| Entrez: | 9902 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CD280 antigen; CD280; CD280C-type mannose receptor 2; CLEC13E; CLEC13EUPAR-associated protein; Endo180; ENDO180C-type lectin domain family 13 member E; Endocytic receptor 180; KIAA0709FLJ35911; Macrophage mannose receptor 2; mannose receptor, C type 2; Mrc2; uPARAP; UPARAPendocytic receptor (macrophage mannose receptor family); urokinase plasminogen activator receptor-associated protein; Urokinase receptor-associated protein; Urokinase-type plasminogen activator receptor-associated protein
Molecular Weight
Mass (kDA):
166.674 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q23.2 |
| Sequence: | 17; NC_000017.11 (62627670..62693597) |
Tissue Specificity
Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.
Subcellular Localizations
Membrane; Single-pass type I membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Invasion
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Neoplasm Metastasis
- Neoplasm Invasiveness
- Fibrosis
- Tissue Adhesions
- Mammary Neoplasms
- Thyroid Neoplasm
- Ureteral Obstruction
Interacting Proteins
- Col1a1
Pathways
- Cell Migration
- Endocytosis
- Secretion
- Plasminogen Activation
- Tissue Remodeling
- Pathogenesis
- Proteolysis
- Virulence
- Cell Motility
- Cell Differentiation
- Glycosylation
- Localization
- Transport
PTMs
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MRC2
bosterbio.com/bosterbio-gene-info-cards/MRC2
References
PMID: 10636902 by Behrendt N., et al. A urokinase receptor-associated protein with specific collagen binding properties.
PMID: 10683150 by Sheikh H., et al. Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells and macrophages and functions as a lectin receptor.