Kelch-like protein 21 Antibodies

AND KLHL21 ELISA kits, Kelch-like protein 21 Proteins

Many biological assays use antibodies to detect Kelch-like protein 21, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Kelch-like protein 21 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Kelch-like protein 21 antibodies...

We validate the specificity of these antibodies to Kelch-like protein 21 by testing them on tissues known to express KLHL21 positively and negatively. Browse below to find the KLHL21 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KLHL21 Infographic by Boster Bio

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Anti-KLHL21 Monoclonal Antibody

4 Q&As

Human

IHC, WB

$399
Cat # A12797
100μl

KLHL21 Overview

Facts about Kelch-like protein 21.

KLHL21 3D structure. Source: alphafold

Kelch-like protein 21 (KLHL21)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB.

Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome. .

Gene Information

Human
Gene Name:	KLHL21
Uniprot:	Q9UJP4
Entrez:	9903

Family

Belongs to:

No superfamily

Alternative Names

kelch-like 21 (Drosophila); Kelch-Like Protein 21; KIAA0469; KLHL21

Molecular Weight

Mass (kDA):
66.617 kDA

Genomic Context


Human

Location:	1p36.31
Sequence:	1; NC_000001.11 (6590724..6602869, complement)

Subcellular Localizations

Cytoplasm, cytoskeleton, spindle. Localizes to the spindle midzone and targets CUL3 to this region.

Pathways

Mitosis
Anaphase
Cytokinesis

PTMs

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KLHL21

References

PMID: 14528312 by Furukawa M., et al. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.

PMID: 19995937 by Maerki S., et al. The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis.