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- Table of Contents
Facts about CDK-activating kinase assembly factor MAT1.
CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
Human | |
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Gene Name: | MNAT1 |
Uniprot: | P51948 |
Entrez: | 4331 |
Belongs to: |
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No superfamily |
CAP35; CDK7/cyclin-H assembly factor; cyclin G1 interacting protein; Cyclin-G1-interacting protein; MAT1TFB3; menage a trois 1 (CAK assembly factor); menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis); Menage a trois; p35; p36; RING finger protein 66; RING finger protein MAT1; RNF66CDK-activating kinase assembly factor MAT1
Mass (kDA):
35.823 kDA
Human | |
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Location: | 14q23.1 |
Sequence: | 14; NC_000014.9 (60734735..60969965) |
Highest levels in colon and testis. Moderate levels are present thymus, prostate, ovary, and small intestine. The lowest levels are found in spleen and leukocytes.
Nucleus.
MAT1 Cell-Based ELISA kit is a highly sensitive, convenient and high-throughput instrument that monitors MAT1 gene expression profiles in cells. It measures the relative amount of MAT1 in cultured cell lines and is useful for screening for drug and treatment effects. This kit is not available individually and can be used with all Boster products. Scientists all over the globe can use this kit to test various Boster products.
Boster Bio is the right place to look if you're searching for a KHDRBS2-quality antibody. Boster has a wide variety of quality antibodies for use in Western blotting, immunohistochemistry, and ELISA. Boster antibodies are highly specific, and have a high affinity to the target protein. Refer to the product specifications for more information.
Multi-platform validation of the Boster Bio Anti-Bax(MNAT1) Antibody was used. This method uses avidins to locate proteins. It is usually Horseradish Peroxide, HRP. This process produces high-specific results with low background. Other detection methods have been developed using organic polymers and polysaccharides. Boster Bio offers product credits to the first reviewers. Boster Bio continues to reward scientists around the world for their contributions to science.
PMID: 8521818 by Tassan J.-P., et al. In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein.
PMID: 8521393 by Yee A., et al. Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor.