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- Table of Contents
1 Citations 1 Q&As
1 Citations 3 Q&As
Facts about Stromelysin-3.
Human | |
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Gene Name: | MMP11 |
Uniprot: | P24347 |
Entrez: | 4320 |
Belongs to: |
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peptidase M10A family |
EC 3.4.24; EC 3.4.24.-; EC 3.4.24.24; matrix metallopeptidase 11 (stromelysin 3); matrix metalloproteinase 11 (stromelysin 3); Matrix metalloproteinase-11; MMP11; MMP-11; SL-3; ST3; STMY3stromelysin 3; stromelysin III; stromelysin-3
Mass (kDA):
54.59 kDA
Human | |
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Location: | 22q11.23 |
Sequence: | 22; NC_000022.11 (23772849..23784316) |
Specifically expressed in stromal cells of breast carcinomas.
Secreted, extracellular space, extracellular matrix.
You may have heard of MMP11 and MMP12, but what exactly is this molecule? And how does it work? You're probably wondering how it's used in the body. Here are some of the most common applications. Read on to find out! Listed below are some of the best uses of this molecule in the body. This protein is very important for the health of your colon.
In vitro and in vivo studies of a therapeutic MMP11 antibody have demonstrated that it is effective in blocking the formation of osteoclasts. In the latter studies, MMP11 depletion resulted in a 60 percent reduction in infiltration rates. In contrast, overexpression of the MMP11 marker partially restored the migration and invasion of PC9 cells. While there are some limitations associated with the use of this antibody in vivo studies, the results are encouraging.
Interestingly, MMP11 is not secreted as a pro-MMP, but is already active upon secretion. It is activated intracellularly by the protein furin via a constitutive secretory pathway in the trans-Golgi network. The MMP11 gene expression correlates with cancer progression and may also be related to a tumor's functional ability to evade immune surveillance.
To determine if MMP11 antibodies are effective in reducing the tumor load, an immunohistochemistry study was conducted in LUAD cells. The anti-MMP11 antibody treatment significantly inhibited LUAD cell proliferation and migration in xenograft models, but further studies are needed to determine the molecular mechanism and determine efficacy and safety. In addition, the research indicates that MMP11 antibody therapy has an important role in reducing the tumor burden.
Although MMP-11 expression levels have decreased in colon cancer, it is still an important early diagnostic marker. Early detection can significantly improve survival. While colon cancer diagnosis by colonoscopy plus biopsy remains the gold standard for diagnosing the disease, it is often accompanied by a less invasive and less costly fecal occult blood test. The advent of novel biomarkers could help us develop noninvasive and highly sensitive diagnostics.
In vitro studies using MMP11 antibodies, an antibody with a concentration as low as 1 mg/mL significantly inhibited cell growth. This suggests that antibodies that inhibit MMP11 are an effective therapeutic intervention in LUAD. There is a significant potential for this therapy. So, if you are considering using antibodies against the MMP11 marker, you should read Boster Bio's article.
The MMP11 marker is a tumor enhancer. It is found in most types of cancer and is associated with advanced clinicopathological staging and poor prognosis. It is also known to play a role in signal transduction pathways. However, its precise role in cancer is not yet understood. For this reason, MMP-11 is used in a number of research studies. Here, we will examine the best uses of the MMP11 marker in various cancers.
MMP-11 is a specialized extracellular proteolytic enzyme that is involved in the remodeling of extracellular matrix proteins. It is also known as stromelysin-3 and insulin-like growth factor-binding protein-1. Most MMPs need to be activated by addition proteinases in the extracellular environment. However, MMP-11 is highly selective and its substrates include insulin-like growth factor-binding protein-1, laminin receptor, and the native alpha3 chain of collagen VI.
In the study of LUAD cell colonies, depletion of MMP11 significantly reduced the number and size of cell colonies. Overexpression of MMP11 was able to partially restore colony formation. The study also indicated that anti-MMP11 antibody can be a promising therapy for LUAD. A number of studies have confirmed that anti-MMP11 antibodies have many applications in cancer research.
Overexpression of MMP11 has been found to cause mitochondrial defects in BAT cells. This translated into enhanced expression of glycolytic genes. This may indicate a more aggressive form of LUAD. These findings suggest that MMP11 is an important tumor suppressor. LUAD tumors are typically characterized by an increase in serum levels of this enzyme. Therefore, it may be used as a biomarker in the early stages of the disease.
Besides being a tumor suppressor, MMP11 has numerous other functions that help protect the body against hepatic steatosis and excessive weight gain. By regulating the synthesis and degradation of fat, MMP11 increases the ability of the body to utilize insulin and protect against diabetes. The underlying role of MMP11 in the human body is unknown, but studies have demonstrated that it supports the metabolic processes of hepatic tissues and the metabolism of glucose and lipids.
MMP11 is an enzyme that helps to maintain metabolic balance in the human body. Its metabolic function helps protect the body from hepatic steatosis and excessive weight gain. Additionally, MMP11 has a role in protecting against the onset of diabetes. However, the best uses of this enzyme are yet to be determined. Continue reading to find out more about MMP11 and its benefits.
In tumor cells, MMP11 is secreted by the cells that make up the tumor. Increasing the level of this protein may be indicative of oncogenic activity. MMP11 levels were measured in human serum using an ELISA assay. Moreover, MMP11 protein was significantly higher in LUAD patients compared to controls. Therefore, MMP11 may be a biomarker of LUAD.
MMP11 plays an important role in both embryonic and adult physiological processes and participates in many human diseases. Invasive cancers express MMP11, and tumors with high MMP11 levels are associated with poor patient survival and aggressiveness. Cancer cells that express MMP11 in their stroma reduce the death of neighboring cells during local invasion. This in turn promotes cancer cells' survival and implantation in the surrounding connective tissues.
MMP11 is produced in E. coli, and is often referred to as Stromelysin-3. MMP11 lacks the cleaving activity of collagen, but has a significant effect on the proliferation and invasion of tumors. Furthermore, it has a functional role in evading the immune surveillance of tumors. As such, it may be an important link between obesity and cancer.
MMP-11 is an enzyme that degrades the MMP peptide substrates very slowly. It is useful for studying the kinetics of this enzyme, screening for inhibitors, and researching the relationship between obesity and cancer. However, despite its utility in cancer research, the question remains whether MMP11 is an important factor in the process of cancer development. So, what are the best uses of the MMP11 marker?
The AUC values of MMP11 are shown in Fig. 4. The most common MMP-cancer pairs were PRAD, LUSC, with MMP11 having the highest AUC value. However, MMP11 and MMP12 were also the most common cancer-related genes with significant predictive values. So, you might want to look into this marker if you have lung cancer or another type of cancer.
The MMP9 Marker in Boster Bio is a potential diagnostic tool in the treatment of aortic aneurysms. This protein is produced in the blood by endothelial cells, smooth muscle cells, and infiltrating inflammatory cells. Because of its high prevalence in aortic aneurysms, its presence in serum may help distinguish patients with this condition.
Research on MMP-9 in cancer has been limited, but the possibility of a biomarker for breast cancer is now possible. Recent studies have found that MMP-9 can be useful in cancer diagnosis and monitoring treatment efficacy. It can also be used to help detect recurrences in patients. In addition, researchers have identified MMP-9 as a biomarker for several cancers, which represents an exciting new application for the research.
The MMP-9 Marker in Boster Bio may also be used to target other diseases associated with IAV infection. Researchers are now evaluating the potential therapeutic benefits of targeting this protein in cancer. This protein has also been linked to cancer, which may require the development of cancer therapies. If you're interested in testing this new biomarker for IAV infection, please contact us today to find out more about how it can help you.
MMP-9 is a potential candidate therapeutic for HIV/AIDS. The enzyme cleaves a variety of viral proteins, including the IAV protein HA. The viral genome attaches to sialic acid-containing glycan receptors on the surface of host cells. Once attached to the target cell, the viral particle is then internalized by endocytosis. This process also involves uncoating the virus, releasing its genome into the cytoplasm.
Another method of measuring MMP-9 is by an electrode-free electrochemical biosensor. The electrode-free biosensor uses a chimeric protein with a donor fluorescent protein and an acceptor fluorescent protein. A signal peptide is embedded in the linker region. The biosensor has been optimized to maximize the efficiency of FRET before MMP-9 cleaves it. In this way, it's possible to measure even low concentrations of MMP-9.
PMID: 1701851 by Basset P., et al. A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas.
PMID: 7657606 by Anglard P., et al. Structure and promoter characterization of the human stromelysin-3 gene.
*More publications can be found for each product on its corresponding product page