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- Table of Contents
Facts about Migration and invasion enhancer 1.
May be involved in a redox-related process. .
Human | |
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Gene Name: | MIEN1 |
Uniprot: | Q9BRT3 |
Entrez: | 84299 |
Belongs to: |
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SelWTH family |
C35; chromosome 17 open reading frame 37; HBV XAg-transactivated protein 4; HBV X-transactivated gene 4 protein; MGC14832; ORB3; protein C17orf37; Protein C35; XTP4RDX12
Mass (kDA):
12.403 kDA
Human | |
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Location: | 17q12 |
Sequence: | 17; NC_000017.11 (39728500..39730563, complement) |
Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma (at protein level).
Cytoplasm, cytosol. Cell membrane; Lipid-anchor; Cytoplasmic side. Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions.
PMID: 17121940 by Evans E.E., et al. C35 (C17orf37) is a novel tumor biomarker abundantly expressed in breast cancer.
PMID: 19503095 by Dasgupta S., et al. Novel gene C17orf37 in 17q12 amplicon promotes migration and invasion of prostate cancer cells.