MICU1 Antibodies

AND MICU1 ELISA kits, MICU1 Proteins

Many biological assays use antibodies to detect MICU1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MICU1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MICU1 antibodies...

We validate the specificity of these antibodies to MICU1 by testing them on tissues known to express MICU1 positively and negatively. Browse below to find the MICU1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MICU1 Infographic by Boster Bio

All MICU1 Products

Product

Figures

Specificity

Applications

Price

Anti-MICU1/Cbara1 Monoclonal Antibody

7 Q&As

Human, Mouse, Rat

IHC, WB

$399
Cat # A01895
100μl

CBARA1 (MICU1) (NM_006077) Human Recombinant Protein

$1249
Cat # PROTQ9BPX6
20 µg

MICU1 Overview

Facts about Calcium uptake protein 1, mitochondrial.

MICU1 3D structure. Source: alphafold

Calcium uptake protein 1, mitochondrial (MICU1)

Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level through its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, based on the concentration of calcium.

MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221).

Gene Information

Human
Gene Name:	MICU1
Uniprot:	Q9BPX6
Entrez:	10367

Family

Belongs to:

MICU1 family

Alternative Names

Allergen Hom s 4; ara CALC; Atopy-related autoantigen CALC; CALCDKFZp564C246; calcium binding atopy-related autoantigen 1; Calcium-binding atopy-related autoantigen 1; MICU1mitochondrial; mitochondrial calcium uptake 1

Molecular Weight

Mass (kDA):
54.351 kDA

Genomic Context


Human

Location:	10q22.1
Sequence:	10; NC_000010.11 (72367326..72626191, complement)

Tissue Specificity

Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells.

Subcellular Localizations

Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion intermembrane space.

Diseases

Dermatitis
Dermatitis, Atopic
Inflammation
Anaphylaxis
Rhinorrhea
Malignant Squamous Cell Neoplasm
Heart Failure
Diabetes Mellitus
Carcinoma

Allergic Rhinitis (disorder)
Asthma
Conjunctivitis
Dermatologic Disorders

Pathways

Transport
Cell Death
Oxidative Phosphorylation
Rna Interference
Insulin Secretion
Anaphylaxis
Localization

Secretion
Autophagy

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MICU1

References

PMID: 9806765 by Natter S., et al. Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients.

PMID: 16002733 by Aichberger K.J., et al. Hom s 4, an IgE-reactive autoantigen belonging to a new subfamily of calcium-binding proteins, can induce Th cell type 1-mediated autoreactivity.