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- Table of Contents
Facts about [F-actin]-monooxygenase MICAL3.
Appears to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this procedure and implicates RAB8A associated with exocytotic vesicles.
Human | |
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Gene Name: | MICAL3 |
Uniprot: | Q7RTP6 |
Entrez: | 57553 |
Belongs to: |
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Mical family |
microtubule associated monoxygenase, calponin and LIM domain containing 3
Mass (kDA):
224.295 kDA
Human | |
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Location: | 22q11.21 |
Sequence: | 22; NC_000022.11 (17787649..18024561, complement) |
Ubiquitous.
Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Nucleus. Midbody. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, cilium basal body. Mainly localizes in the nucleus.
PMID: 12110185 by Terman J.R., et al. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.
PMID: 15694364 by Fischer J., et al. The MICAL proteins and rab1: a possible link to the cytoskeleton?