[F-actin]-monooxygenase MICAL3 (MICAL3)

Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, in addition, it functions as a NADPH oxidase producing H(2)O(2).

Appears to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this procedure and implicates RAB8A associated with exocytotic vesicles.