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- Table of Contents
Facts about [F-actin]-monooxygenase MICAL1.
Acts as a cytoskeletal regulator which connects NEDD9 to intermediate filaments. Also functions as a negative regulator of apoptosis through its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4.
Human | |
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Gene Name: | MICAL1 |
Uniprot: | Q8TDZ2 |
Entrez: | 64780 |
Belongs to: |
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Mical family |
CasL interacting molecule; DKFZp434B1517; FLJ11937; FLJ21739; MICALMolecule interacting with CasL protein 1; microtubule associated monoxygenase, calponin and LIM domain containing 1; NEDD9 interacting protein with calponin homology and LIM domains; NEDD9-interacting protein with calponin homology and LIM domains; NICALMICAL-1
Mass (kDA):
117.875 kDA
Human | |
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Location: | 6q21 |
Sequence: | 6; NC_000006.12 (109444062..109465968, complement) |
Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells.
Cytoplasm. Cytoplasm, cytoskeleton. Midbody. Accumulates transiently at the abscission site before abscission occurs.
PMID: 11827972 by Suzuki T., et al. MICAL, a novel CasL interacting molecule, associates with vimentin.
PMID: 11214971 by Hattori A., et al. Characterization of long cDNA clones from human adult spleen.