Protein MEMO1 (MEMO1)

May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling.

The MEMO1-RHOA-DIAPH1 signaling pathway plays an significant role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 into the cell membrane, via the regulation of GSK3B activity.