MECOM Antibodies

AND MECOM ELISA kits, MECOM Proteins

Many biological assays use antibodies to detect MECOM, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MECOM in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MECOM antibodies...

We validate the specificity of these antibodies to MECOM by testing them on tissues known to express MECOM positively and negatively. Browse below to find the MECOM antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MECOM Infographic by Boster Bio

All MECOM Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-PRDM3 MECOM Antibody

Human

ELISA, IHC, WB

$380
Cat # A04590
100ul

Human EVI-1 Recombinant Protein

SDS-PAGE, Denatured

$250
Cat # PROTQ03112
Starting from 4ug

Anti-EVI1/MECOM Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A04590-1
100 μg/vial

EVI1 (MECOM) (NM_005241) Human Over-expression Lysate

Human

$960
Cat # LS002122
100 µg

MECOM Overview

Facts about Histone-lysine N-methyltransferase MECOM.

MECOM 3D structure. Source: alphafold

Histone-lysine N-methyltransferase MECOM (MECOM)

Isoform 1: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their saying. Oncogene which plays a role in development, cell proliferation and differentiation.

May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.

Gene Information

Human
Gene Name:	MECOM
Uniprot:	Q03112
Entrez:	2122

Family

Belongs to:

No superfamily

Alternative Names

AML1-EVI-1 fusion protein; AML1-EVI-1; ecotropic viral integration site 1; Ecotropic virus integration site 1 protein homolog; EVI1; EVI-1; EVI1MDS1-EVI1; MDS1 and EVI1 complex locus protein EVI1; MDS1 and EVI1 complex locus protein MDS1; MDS1 and EVI1 complex locus; MDS1; MECOM; MGC163392; MGC97004; Myelodysplasia syndrome 1 protein; myelodysplasia syndrome 1; Myelodysplasia syndrome-associated protein 1; oncogene EVI1; PRDM3; zinc finger protein Evi1

Molecular Weight

Mass (kDA):
138.136 kDA

Genomic Context


Human

Location:	3q26.2
Sequence:	3; NC_000003.12 (169083499..169663781, complement)

Subcellular Localizations

Nucleus. Nucleus speckle. Cytoplasm.

Diseases

Leukemia
Myeloid Leukemia
Leukemia, Myelocytic, Acute
Myeloid Leukemia, Chronic
Dysmyelopoietic Syndromes
Malignant Neoplasms
Chromosomal Translocation
Leukemogenesis
Cytogenetic Abnormality
Neoplasms
Blast Phase
Cell Transformation, Neoplastic

Hematologic Neoplasms
Malignant Paraganglionic Neoplasm
Chromosome Inversion
Monosomy
Monosomy 7
Carcinoma

Interacting Proteins

Ctbp2
FOS
RBBP4
SIRT1
UXT

Pathways

Pathogenesis
Cell Proliferation
Cell Growth
Oncogenesis
Methylation
Cell Cycle
Cell Differentiation
Interphase
Localization
Cell Death
Dna Hypermethylation
Cell Adhesion
Contact Inhibition

Dna Methylation
Metaphase
Megakaryocyte Differentiation
Myeloid Cell Differentiation
Macrophage Differentiation
Response To Erythropoietin
Heterochromatin Organization

PTMs

Methylation
Acetylation

Phosphorylation
Deacetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MECOM

References

PMID: 2115646 by Morishita K., et al. Unique expression of the human Evi-1 gene in an endometrial carcinoma cell line: sequence of cDNAs and structure of alternatively spliced transcripts.

PMID: 8643684 by Fears S., et al. Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family.