MCU Antibodies

AND MCU ELISA kits, MCU Proteins

Many biological assays use antibodies to detect MCU, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MCU in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MCU antibodies...

We validate the specificity of these antibodies to MCU by testing them on tissues known to express MCU positively and negatively. Browse below to find the MCU antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MCU Infographic by Boster Bio

All MCU Products

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Specificity

Applications

Price

Anti-MCU Antibody Picoband®

Human, Monkey, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A00685-1
100 μg/vial

MCU (NM_138357) Human Over-expression Lysate

Human

$628
Cat # LS090550
100 µg

MCU Overview

Facts about Calcium uniporter protein, mitochondrial.

MCU 3D structure. Source: alphafold

Calcium uniporter protein, mitochondrial (MCU)

Mitochondrial inner membrane calcium uniporter which mediates calcium uptake into mitochondria (PubMed:21685888, PubMed:21685886, PubMed:23101630, PubMed:22904319, PubMed:23178883, PubMed:22829870, PubMed:22822213, PubMed:24332854, PubMed:23755363, PubMed:26341627). Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (PubMed:23755363).

Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down- regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 raises MCU action (PubMed:24560927, PubMed:26903221).

Gene Information

Human
Gene Name:	MCU
Uniprot:	Q8NE86
Entrez:	90550

Family

Belongs to:

MCU (TC 1.A.77) family

Alternative Names

C10orf42; coiled-coil domain containing 109A; coiled-coil domain-containing protein 109A; FLJ46135

Molecular Weight

Mass (kDA):
39.867 kDA

Genomic Context


Human

Location:	10q22.1
Sequence:	10; NC_000010.11 (72692131..72887694)

Subcellular Localizations

Mitochondrion inner membrane; Multi-pass membrane protein.

Diseases

Gastroesophageal Reflux Disease
Vesico-ureteral Reflux
Urinary Tract Infection
Urethral Diseases
Pathological Dilatation
Infective Disorder
Cicatrix
Hydronephrosis
Stenosis
Kidney Diseases
Urologic Diseases
Urethral Obstruction
Urethral Stricture

Edema
Hypertensive Disease
Urethral Valves
Kidney Failure
Urinary Incontinence
Infection Of Kidney
Malignant Neoplasms

Interacting Proteins

MCUR1
MICU1

Pathways

Micturition
Transport
Cell Death
Pathogenesis
Oxidative Phosphorylation
Localization
Programmed Cell Death
Uniport
Insulin Secretion
Excretion
Secretion
Mitochondrial Depolarization
Carbohydrate Utilization

Flight
Fibrinolysis
Mating
Glomerular Filtration
Regeneration
Cytokine Production
Locomotion

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MCU

References

PMID: 21685888 by De Stefani D., et al. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.

PMID: 21685886 by Baughman J.M., et al. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.