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- Table of Contents
Facts about StAR-related lipid transfer protein 13.
GTPase-activating protein for RhoA, and perhaps for Cdc42.
May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility.Acts a tumor suppressor in hepatocellular carcinoma cells. .
Human | |
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Gene Name: | STARD13 |
Uniprot: | Q9Y3M8 |
Entrez: | 90627 |
Belongs to: |
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No superfamily |
ARHGAP37; DLC2; FLJ37385; GT650; Rho GTPase activating protein on chromosome 13q12; StAR-related lipid transfer (START) domain containing 13
Mass (kDA):
124.967 kDA
Human | |
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Location: | 13q13.1-q13.2 |
Sequence: | 13; NC_000013.11 (33103137..33676829, complement) |
Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.
Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet.
PMID: 12531887 by Ching Y.-P., et al. Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma.
PMID: 14697242 by Nagaraja G.M., et al. Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins.