Mucolipin-2 Antibodies

AND Mcoln2 ELISA kits, Mucolipin-2 Proteins

Many biological assays use antibodies to detect Mucolipin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Mucolipin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Mucolipin-2 antibodies...

We validate the specificity of these antibodies to Mucolipin-2 by testing them on tissues known to express Mcoln2 positively and negatively. Browse below to find the Mcoln2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Mcoln2 Infographic by Boster Bio

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MCOLN2 (NM_153259) Human Over-expression Lysate

Human

$628
Cat # LS255231
100 µg

Mcoln2 Overview

Facts about Mucolipin-2.

Mucolipin-2 (Mcoln2)

Nonselective cation channel likely playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)- permeable cation channel with inwardly rectifying activity (PubMed:19763610).

May trigger ARF6 and participate in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (By similarity). May play a role in immune processes.

Gene Information

Mouse
Gene Name:	Mcoln2
Uniprot:	Q8K595
Entrez:	68279

Family

Belongs to:

transient receptor (TC 1.A.4) family

Alternative Names

FLJ36691; mucolipin 2; mucolipin-2; TRPML2; TRP-ML2

Molecular Weight

Mass (kDA):
65.45 kDA

Genomic Context


Mouse

Location:	3\|3 H2
Sequence:	3;

Tissue Specificity

Isoform 1 is widely expressed at very low levels. Isoform 2 is expressed at high levels in lymphoid tissues (thymus and spleen) and kidney, and at moderate levels in heart, lung, liver and stomach. Expressed in activated macrophages and microglia (at protein level).

Diseases

Mucolipidoses
Mucolipidosis Type Iv
Complete Hearing Loss
Chikungunya Virus Infection
Cytopathic Effect
Encephalomyelitis, Equine
Nerve Degeneration
Hepatitis
Strabismus
Hepatitis C
Impairments, Visual
Venezuelan Equine Encephalomyelitis
Polycystic Kidney, Autosomal Dominant

Immunologic Deficiency Syndromes
Yellow Fever
Polycystic Kidney Diseases
Lysosomal Storage Diseases
Impairment (finding)
Hiv Infections
Encephalitis

Pathways

Transport
Localization
Cell Death
Autophagy
Fertilization
Pigmentation
Endocytosis
Membrane Fusion
Protein Transport
Vesicle Fusion
Ion Homeostasis

Cell Maturation
Mating
Pathogenesis
Exocytosis
Mating Behavior
Rna Interference

PTMs

Disulfide bond

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Mcoln2

References

PMID: 12403827 by Di Palma F., et al. Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice.

PMID: 17050035 by Song Y., et al. TRPML cation channels regulate the specialized lysosomal compartment of vertebrate B-lymphocytes.