MTO1 Antibodies

AND MTO1 ELISA kits, MTO1 Proteins

Many biological assays use antibodies to detect MTO1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MTO1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MTO1 antibodies...

We validate the specificity of these antibodies to MTO1 by testing them on tissues known to express MTO1 positively and negatively. Browse below to find the MTO1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MTO1 Infographic by Boster Bio

All MTO1 Products

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Specificity

Applications

Price

MTO1 (NM_012123) Human Recombinant Protein

$1249
Cat # PROTQ9Y2Z2
20 µg

MTO1 (NM_012123) Human Over-expression Lysate

Human

$628
Cat # LS025821
100 µg

MTO1 Overview

Facts about Protein MTO1 homolog, mitochondrial.

MTO1 3D structure. Source: alphafold

Protein MTO1 homolog, mitochondrial (MTO1)

Involved from the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. .

Gene Information

Human
Gene Name:	MTO1
Uniprot:	Q9Y2Z2
Entrez:	25821

Family

Belongs to:

MnmG family

Alternative Names

EC 1.1.1.40; EC 6.3.5; homolog of yeast Mto1; mitochondrial MTO1-3; mitochondrial translation optimization 1 homolog (S. cerevisiae); protein MTO1 homolog, mitochondrial

Molecular Weight

Mass (kDA):
79.964 kDA

Genomic Context


Human

Location:	6q13
Sequence:	6; NC_000006.12 (73461737..73509236)

Tissue Specificity

Ubiquitously expressed in various tissues, but with a markedly elevated expression in tissues of high metabolic rates including cochlea.

Subcellular Localizations

Mitochondrion.

Diseases

Complete Hearing Loss
Mitochondrial Diseases
Sensorineural Hearing Loss (disorder)
Hypertrophic Cardiomyopathy
Acidosis
Malnutrition
Congenital Abnormality
Deafness Congenital
Merrf Syndrome
Epilepsy
Cardiomyopathies

Epilepsies, Myoclonic
Hypertrophy
Renal Cell Carcinoma
Acidosis, Lactic
Myoclonus
Dysequilibrium Syndrome

Pathways

Translation
Trna Modification
Microtubule Nucleation
Mitochondrial Translation
Pathogenesis
Mitochondrial Trna Modification
Rna Modification
Mitochondrial Rna Modification
Mitosis
Brain Development

Cellular Process
Localization
Methylation
Cell Cycle
Rrna Modification

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MTO1

References

PMID: 12011058 by Li X.M., et al. Isolation and characterization of the putative nuclear modifier gene MTO1 involved in the pathogenesis of deafness-associated mitochondrial 12 S rRNA A1555G mutation.

PMID: 22608499 by Ghezzi D., et al. Mutations of the mitochondrial-tRNA modifier MTO1 cause hypertrophic cardiomyopathy and lactic acidosis.