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MCM3AP Antibodies
AND MCM3AP ELISA kits, MCM3AP Proteins
Many biological assays use antibodies to detect MCM3AP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MCM3AP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MCM3AP antibodies...
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MCM3AP Infographic by Boster Bio
All MCM3AP Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA
$480
Cat # EKC1234
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1234
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A05445-2
100 µg/vial
Cat # A05445-2
100 µg/vial
MCM3AP Overview
Facts about Germinal-center associated nuclear protein.
Germinal-center associated nuclear protein (MCM3AP)
Isoform GANP: Essential for the creation of high- affinity B-cells against T-cell-dependent antigens by changing somatic hypermutation in the IgV-regions. May have stimulation- dependent DNA primase activity that would generate additional RNA primers in very rapidely proliferating cells and would support clonal growth of differentiating B-cells (By similarity).
Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) into the atomic entrance of the nuclear pore complex (atomic basket).
Gene Information
| Human | |
|---|---|
| Gene Name: | MCM3AP |
| Uniprot: | O60318 |
| Entrez: | 8888 |
Family
| Belongs to: |
|---|
| SAC3 family |
Alternative Names
80 kDa MCM3-associated protein; FLJ44336; GANPFLJ45306; human mRNA for MCM3 import factor10Protein GANP; KIAA0572MAP80germinal center-associated nuclear protein; Map80; MCM3 import protein; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein; MCM3 minichromosome maintenance deficient 3 associated protein; minichromosome maintenance complex component 3 associated protein; minichromosome maintenance deficient (S. cerevisiae) 3-associated protein; minichromosome maintenance deficient 3-associated protein
Molecular Weight
Mass (kDA):
218.405 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 21q22.3 |
| Sequence: | 21; NC_000021.9 (46235130..46286297, complement) |
Subcellular Localizations
[Isoform GANP]: Nucleus envelope. Nucleus, nuclear pore complex. Nucleus, nucleoplasm. Chromosome. Predominantly located at the nuclear envelope, facing the nucleus interior (PubMed:20005110, PubMed:21195085, PubMed:23591820). Localization at the nuclear pore complex requires NUP153, TPR and ALYREF/ALY (PubMed:23591820, PubMed:22307388). Also found associated with chromatin (PubMed:23652018). In B-cells, targeted to the immunoglobulin variable region genes (PubMed:23652018).; [Isoform MCM3AP]: Cytoplasm. Nucleus. Translocates into the nucleus in the presence of MCM3 (PubMed:12226073). Associat
Diseases
- Neoplasms
- Malignant Paraganglionic Neoplasm
- Cholangiocarcinoma
- Aneuploidy
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Inflammation
- Monosomy
- Bile Duct Neoplasms
- Melanoma
- Neurodegenerative Disorders
- Glioma
- Confusion
Pathways
- Dna Replication
- Localization
- Cell Cycle
- Cell Proliferation
- Transport
- Cell Activation
- B Cell Activation
- Nuclear Export
- Mitosis
- Dna Repair
- Regulation Of Dna Repair
- Cellular Senescence
- Dna Integration
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MCM3AP
bosterbio.com/bosterbio-gene-info-cards/MCM3AP
References
PMID: 11024281 by Abe E., et al. Structure, expression, and chromosomal localization of the human gene encoding a germinal center-associated nuclear protein (GANP) that associates with MCM3 involved in the initiation of DNA replication.
PMID: 9712829 by Takei Y., et al. Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization.