MBNL3 Antibodies

AND MBNL3 ELISA kits, MBNL3 Proteins

Many biological assays use antibodies to detect MBNL3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MBNL3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MBNL3 antibodies...

We validate the specificity of these antibodies to MBNL3 by testing them on tissues known to express MBNL3 positively and negatively. Browse below to find the MBNL3 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MBNL3 Infographic by Boster Bio

All MBNL3 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

MBNL3 (NM_018388) Human Recombinant Protein

$813
Cat # PROTQ9NUK0
20 µg

MBNL3 (NM_018388) Human Over-expression Lysate

Human

$628
Cat # LS055796
100 µg

Anti-MBNL3 Antibody Picoband®

Human

ELISA, IF, ICC, WB

$370
Cat # A08298
100 µg/vial

MBNL3 Overview

Facts about Muscleblind-like protein 3.

MBNL3 3D structure. Source: alphafold

Muscleblind-like protein 3 (MBNL3)

Mediates pre-mRNA alternative splicing regulation. Acts equally as activator or repressor of splicing on particular pre-mRNA targets.

Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins.

Gene Information

Human
Gene Name:	MBNL3
Uniprot:	Q9NUK0
Entrez:	55796

Family

Belongs to:

muscleblind family

Alternative Names

CHCRMBLX39FLJ11316; Cys3His CCG1-required protein; FLJ97142; MBXLMBLX; muscleblind-like 3 (Drosophila); muscleblind-like protein 3; Muscleblind-like X-linked protein; Protein HCHCR

Molecular Weight

Mass (kDA):
38.532 kDA

Genomic Context


Human

Location:	Xq26.2
Sequence:	X; NC_000023.11 (132369314..132490035, complement)

Tissue Specificity

Highly expressed in the placenta.

Subcellular Localizations

Nucleus. Cytoplasm. Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts.

Diseases

Myotonic Dystrophy
Dystrophy
Muscular Dystrophy
Trinucleotide Repeat Expansion
Tissue Adhesions
Dystrophia Myotonica 2
Abnormal Degeneration
Muscle Degeneration
Weakness
Muscular Dystrophy, Duchenne

Nystagmus
Myopathy
Nervousness
Muscle Weakness
Congenital Nystagmus

Interacting Proteins

DAB1

Pathways

Pathogenesis
Localization
Cell Adhesion
Regulation Of Macrophage Activation
Mrna Splicing
Cell Cycle
Cell Fate Determination
Eye Development

Rna Splicing
Macrophage Activation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MBNL3

References

PMID: 12297108 by Squillace R.M., et al. Inhibition of muscle differentiation by the novel muscleblind-related protein CHCR.

PMID: 11929853 by Fardaei M., et al. Three proteins, MBNL, MBLL and MBXL, co-localize in vivo with nuclear foci of expanded-repeat transcripts in DM1 and DM2 cells.