MARK4 Antibodies

AND MARK4 ELISA kits, MARK4 Proteins

Many biological assays use antibodies to detect MARK4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MARK4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MARK4 antibodies...

We validate the specificity of these antibodies to MARK4 by testing them on tissues known to express MARK4 positively and negatively. Browse below to find the MARK4 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MARK4 Infographic by Boster Bio

All MARK4 Products

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Product

Figures

Specificity

Applications

Price

Anti-MARK4 Antibody

13 Q&As

Human, Mouse

ELISA, IF, ICC

$335
Cat # A04672-1
100ul

Anti-MARK4 Mouse Monoclonal Antibody [Clone ID: OTI9B7]

Human, Mouse, Rat

IHC, WB

$523
Cat # M04672
100 µl

MARK4 (NM_031417) Human Over-expression Lysate

Human

$960
Cat # LS057787
100 µg

MARK4 Overview

Facts about MAP/microtubule affinity-regulating kinase 4.

MARK4 3D structure. Source: alphafold

MAP/microtubule affinity-regulating kinase 4 (MARK4)

Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942).
Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762).

Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532).

Gene Information

Human
Gene Name:	MARK4
Uniprot:	Q96L34
Entrez:	57787

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11; EC 2.7.11.1; FLJ12177; FLJ90097; KIAA1860MARK4L; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase like 1; MAP/microtubule affinity-regulating kinase-like 1; MARK4 serine/threonine protein kinase; MARKL1L; MARKL1MARK4S; Nbla00650

Molecular Weight

Mass (kDA):
82.52 kDA

Genomic Context


Human

Location:	19q13.32
Sequence:	19; NC_000019.10 (45251271..45305284)

Tissue Specificity

Ubiquitous. Isoform 2 is brain-specific (PubMed:11326310). Expressed at highest levels in brain and testis. Also expressed in heart, lung, liver, muscle, kidney and spleen (PubMed:14594945).

Subcellular Localizations

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm. Cell projection, dendrite. Localized at the tips of neurite-like processes in differentiated neuroblast cells. Detected in the cytoplasm and neuropil of the hippocampus.

Diseases

Neoplasms
Alzheimer's Disease
Malignant Neoplasms
Glioma
Glioblastoma
Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent
Autoimmunity
Prion Diseases
Brain Ischemia
Neurodegenerative Disorders
Malignant Neoplasm Of Breast
Dementia

Primary Glioblastoma
Carcinogenesis
Insulin Resistance
Fatal Familial Insomnia
Cardiovascular Diseases
Creutzfeldt-jakob Disease
Mammary Neoplasms

Interacting Proteins

CDC42
KRT31
PARD6G
PNMA1
PRKCI

STK11
TUBG1
YWHAH

Pathways

Energy Homeostasis
Localization
Pathogenesis
Hyperphosphorylation
Cell Migration
Cell Proliferation
Cellular Senescence
Aging
Establishment Of Cell Polarity
Muscle Contraction
Hypersensitivity
Senescence

Glucose Homeostasis
Cell Death
Cell Cycle
Cell Growth
Interphase
Wound Healing
Autophagy

PTMs

Phosphorylation

Ubiquitination

Research Areas

Apoptosis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MARK4

References

PMID: 11326310 by Kato T., et al. Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis.

PMID: 14594945 by Trinczek B., et al. MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes.