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- Table of Contents
3 Q&As
Facts about C-Jun-amino-terminal kinase-interacting protein 2.
May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). .
Human | |
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Gene Name: | MAPK8IP2 |
Uniprot: | Q13387 |
Entrez: | 23542 |
Belongs to: |
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JIP scaffold family |
C-Jun-amino-terminal kinase-interacting protein 2; homologous to mouse JIP-1; IB-2; IB2JIP2Mitogen-activated protein kinase 8-interacting protein 2; islet-brain 2; islet-brain-2; JIP-2; JNK MAP kinase scaffold protein 2; JNK MAP kinase scaffold protein JIP2; JNK-interacting protein 2; mitogen-activated protein kinase 8 interacting protein 2; PRKM8 interacting protein-like; PRKM8IPL
Mass (kDA):
87.975 kDA
Human | |
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Location: | 22q13.33 |
Sequence: | 22; NC_000022.11 (50600793..50613978) |
Expressed mainly in the brain and pancreas, including insulin-secreting cells. In the nervous system, more abundantly expressed in the cerebellum, pituitary gland, occipital lobe and the amygdala. Also expressed in fetal brain. Very low levels found in uterus, ovary, prostate, colon, testis, adrenal gland, thyroid gland and salivary gland.
Cytoplasm. Accumulates in cell surface projections.
PMID: 10490659 by Yasuda J., et al. The JIP group of mitogen-activated protein kinase scaffold proteins.
PMID: 10756100 by Negri S., et al. cDNA cloning and mapping of a novel islet-brain/JNK interacting protein.