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- Table of Contents
Facts about V-type proton ATPase 116 kDa subunit a isoform 2.
May play a role in keeping the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and contributing to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity).
Mouse | |
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Gene Name: | Atp6v0a2 |
Uniprot: | P15920 |
Entrez: | 21871 |
Belongs to: |
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V-ATPase 116 kDa subunit family |
A2; ARCL; ATP6A2; ATP6N1D; ATP6V0; ATPase, H+ transporting, lysosomal V0 subunit a isoform 2; ATPase, H+ transporting, lysosomal V0 subunit a2; infantile malignant osteopetrosis; J6B7; Lysosomal H(+)-transporting ATPase V0 subunit a2; regeneration and tolerance factor; RTF; STV1; TJ6A2V-ATPase; TJ6M; TJ6S; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2; vacuolar proton translocating ATPase 116 kDa subunit a; V-ATPase 116 kDa isoform a2; v-ATPase 116 kDa; VPH1; V-type proton ATPase 116 kDa subunit a isoform 2; v-type proton ATPase 116 kDa subunit a; WSS
Mass (kDA):
98.145 kDA
Mouse | |
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Location: | 5|5 F |
Sequence: | 5; |
Relatively high expression in kidney and liver. Lower levels in the spleen, testis, and skeletal muscle. Also expressed in the thymus.
PMID: 2247090 by Lee C.-K., et al. Cloning of a cDNA for a T cell produced molecule with a putative immune regulatory role.
PMID: 10722719 by Toyomura T., et al. Three subunit a isoforms of mouse vacuolar H+-ATPase. Preferential expression of the a3 isoform during osteoclast differentiation.