MAPK4 Antibodies

AND MAPK4 ELISA kits, MAPK4 Proteins

Many biological assays use antibodies to detect MAPK4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAPK4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAPK4 antibodies...

We validate the specificity of these antibodies to MAPK4 by testing them on tissues known to express MAPK4 positively and negatively. Browse below to find the MAPK4 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MAPK4 Infographic by Boster Bio

All MAPK4 Products

Product

Figures

Specificity

Applications

Price

Anti-MK04 MAPK4 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A06298
100ul

MAPK4 (NM_002747) Human Recombinant Protein

$1249
Cat # PROTP31152
20 µg

Anti-MAPK4 Mouse Monoclonal Antibody [Clone ID: OTI2D7]

Human, Mouse, Rat

IF, IHC, WB

$523
Cat # M06298
100 µl

MAPK4 (NM_002747) Human Over-expression Lysate

Human

$628
Cat # LS005596
100 µg

MAPK4 Overview

Facts about Mitogen-activated protein kinase 4.

MAPK4 3D structure. Source: alphafold

Mitogen-activated protein kinase 4 (MAPK4)

Atypical MAPK protein.
Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5.

The precise purpose of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity).

Gene Information

Human
Gene Name:	MAPK4
Uniprot:	P31152
Entrez:	5596

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11; EC 2.7.11.24; ERK3; Erk3-related; ERK4; ERK-4; Extracellular signal-regulated kinase 4; MAP kinase 4; MAP kinase isoform p63; MAPK 4; MAPK4; mitogen-activated protein kinase 4; p63Mapk; PRKM4; PRKM4p63-MAPK

Molecular Weight

Mass (kDA):
65.922 kDA

Genomic Context


Human

Location:	18q21.1-q21.2
Sequence:	18; NC_000018.10 (50559772..50731826)

Tissue Specificity

High expression in heart and brain.

Subcellular Localizations

Cytoplasm. Nucleus. Translocates to the cytoplasm following interaction with MAPKAPK5.

Diseases

Malignant Neoplasms
Neoplasms
Neoplasm Metastasis
Tissue Adhesions
Adenoma
Embryonal Carcinoma
Malignant Neoplasm Of Breast
Fetal Growth Retardation
Carcinogenesis
Carcinoma
Lupus Erythematosus, Systemic
Lymphoma

Mammary Neoplasms
Pheochromocytoma
Bipolar Disorder
Infective Disorder
Cell Transformation, Neoplastic
Primary Atelectasis, In Perinatal Period
Lung Neoplasms

Interacting Proteins

HSP90AB1

Pathways

Cell Cycle
Cell Adhesion
Cell Migration
Translation
Disease Resistance
Cytokine Production
Cell Death

Immune Response
Localization

PTMs

Phosphorylation

Dephosphorylation

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAPK4

References

PMID: 1319925 by Gonzalez F.A., et al. Heterogeneous expression of four MAP kinase isoforms in human tissues.

PMID: 21177870 by Deleris P., et al. Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.