Mitogen-activated protein kinase 10 (MAPK10)

Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical strain stimulate the stress- activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway.

Subsequently, MAPK10/JNK3 phosphorylates a range of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory functions in the signaling pathways during neuronal apoptosis.