MAP4K1 Antibodies

AND MAP4K1 ELISA kits, MAP4K1 Proteins

Many biological assays use antibodies to detect MAP4K1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAP4K1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAP4K1 antibodies...

We validate the specificity of these antibodies to MAP4K1 by testing them on tissues known to express MAP4K1 positively and negatively. Browse below to find the MAP4K1 antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MAP4K1 Infographic by Boster Bio

All MAP4K1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-MEKKK 1 Antibody

1 Q&As

Human, Mouse

ELISA, IHC-P, WB, IF (paraffin)

$335
Cat # A30542
100ul

Anti-HPK1 (L397) MAP4K1 Antibody

Human, Mouse, Rat

$405
Cat # A07909
100ul

Anti-MAP4K1/HPK1 Antibody Picoband®

Rat

$370
Cat # A07909-2
100 μg/vial

Anti-MAP4K1 Antibody

Human

WB, IHC-P-Leica

$299
Cat # M07909
50 µl

Anti-MAP4K1/HPK1 Antibody Picoband®

Human

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A07909-3
100 μg/vial

MAP4K1 (NM_007181) Human Over-expression Lysate

Human

$960
Cat # LS011184
100 µg

MAP4K1 Overview

Facts about Mitogen-activated protein kinase kinase kinase kinase 1.

MAP4K1 3D structure. Source: alphafold

Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1)

Serine/threonine-protein kinase, which might play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.

Gene Information

Human
Gene Name:	MAP4K1
Uniprot:	Q92918
Entrez:	11184

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11; EC 2.7.11.1; Hematopoietic progenitor kinase; HPK1hematopoietic progenitor kinase 1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; mitogen-activated protein kinase kinase kinase kinase 1

Molecular Weight

Mass (kDA):
91.296 kDA

Genomic Context


Human

Location:	19q13.2
Sequence:	19; NC_000019.10 (38587641..38617953, complement)

Tissue Specificity

Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine.

Diseases

Cell Invasion
Malignant Neoplasms
Neoplasms
Cell Transformation, Neoplastic
Colonic Neoplasms
Malignant Tumor Of Colon
Neoplasm Invasiveness
Carcinoma
Autoimmunity
Bladder Neoplasm
Adenocarcinoma
Neoplasm Metastasis
Cerebellar Neoplasms

Tumor Progression
Malignant Neoplasm Of Brain
Malignant Paraganglionic Neoplasm
Autoimmune Diseases
Brain Neoplasms
Malignant Neoplasm Of Urinary Bladder
Autoimmune Reaction

Interacting Proteins

ABL1
CRK
CRKL
FYN
GRB2

NCK1
PIK3R1
PLCG1
SLAMF1

Pathways

Programmed Cell Death
Cell Death
Cell Migration
Cell Proliferation
Cell Cycle
T Cell Proliferation
Cell Development

Oncogenesis

PTMs

Phosphorylation
Cleavage

Methylation
Ubiquitination

Research Areas

Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAP4K1

References

PMID: 8824585 by Hu M.C.-T., et al. Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade.

PMID: 24362026 by Wang H., et al. The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1.