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- Table of Contents
Facts about Ras association domain-containing protein 1.
Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.
Human | |
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Gene Name: | RASSF1 |
Uniprot: | Q9NS23 |
Entrez: | 11186 |
Belongs to: |
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No superfamily |
123F2; NORE2A; pancreas-specific ras association domain family 1 protein; Ras association (RalGDS/AF-6) domain family member 1; ras association domain-containing protein 1; RASSF1A; RDA32cardiac-specific ras association domain family 1 protein; REH3P21; tumor suppressor protein RDA32; WUGSC:H_LUCA12.5
Mass (kDA):
39.219 kDA
Human | |
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Location: | 3p21.31 |
Sequence: | 3; NC_000003.12 (50329786..50340936, complement) |
Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells.
[Isoform A]: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells. Colocalizes with MDM2 in the nucleus.; [Isoform C]: Nucleus. Predominantly nuclear.
PMID: 10888881 by Dammann R., et al. Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3.
PMID: 11333291 by Burbee D.G., et al. Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression.